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Titolo:
Gender difference in cytoprotection induced by estrogen on female and malebovine aortic endothelial cells
Autore:
Si, ML; Al-Sharafi, B; Lai, CC; Khardori, R; Chang, CS; Su, CY;
Indirizzi:
So Illinois Univ, Sch Med, Div Endocrinol Metab & Mol Med, Dept Internal Med, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 Med, Springfield, IL 62794 USA So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 acol, Springfield, IL 62794 USA
Titolo Testata:
ENDOCRINE
fascicolo: 3, volume: 15, anno: 2001,
pagine: 255 - 262
SICI:
1355-008X(200108)15:3<255:GDICIB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONFERS OXIDATIVE PROTECTION; LOW-DENSITY-LIPOPROTEIN; NITRIC-OXIDE SYNTHASE; RECEPTOR GENE; SEX-HORMONES; HEAT-SHOCK; 17-BETA-ESTRADIOL; PROLIFERATION; ESTRADIOL; STRESS;
Keywords:
17 beta-estradiol; bovine aortic endothelial cells; cellular antioxidant defenses; heat-shock response; antioxidant enzymes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Su, CY So Illinois Univ, Sch Med, Div Endocrinol Metab & Mol Med, Dept Internal Med, POB 19230, Springfield, IL 62794 USA So Illinois Univ POB 19230 Springfield IL USA 62794 d, IL 62794 USA
Citazione:
M.L. Si et al., "Gender difference in cytoprotection induced by estrogen on female and malebovine aortic endothelial cells", ENDOCRINE, 15(3), 2001, pp. 255-262

Abstract

Before menopause, women have a lower risk of cardiovascular diseases than men. Studies attribute this gender difference to estrogenic protection in the female cardiovascular system. We have demonstrated that 17 beta -estradiol (E-2) protects female bovine aortic endothelial cells against oxidative injury, probably through the induction of antioxidant enzyme activities. Inthis study, we examined whether E-2 confers a differential protection on male and female cells. Bovine aortic endothelial cells from both genders were preconditioned for 24 h with E-2 (1 nM to 10 muM), and their resistance to paraquat (1 mM, 3 h), a superoxide generator, was measured using an MTT assay. In contrast to the protection observed in female bovine aortic endothelial cells, there was no protective effect by E-2 on male bovine aortic endothelial cells at physiologic concentrations. However, E-2 at 1-10 muM attenuated paraquat's toxicity in both male and female cells, probably throughits direct antioxidant activity. E-2 at I nM increased in female, but not in male, cells the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, which was associated with decreased levels of reactive oxygen species during subsequent paraquat exposure. This suggests that antioxidant enzyme induction plays some role in E-2-augmented oxidative resistance in female endothelial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:46:13