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Titolo: Treating epilepsy in the elderly - Safety considerations
Autore: Arroyo, S; Kramer, G;
- Indirizzi:
- Hosp Clin Barcelona, Unidad Epilepsia, E-08036 Barcelona, Spain Hosp Clin Barcelona Barcelona Spain E-08036 ia, E-08036 Barcelona, Spain Swiss Epilepsy Ctr, Zurich, Switzerland Swiss Epilepsy Ctr Zurich Switzerland Epilepsy Ctr, Zurich, Switzerland
- Titolo Testata:
- DRUG SAFETY
fascicolo: 13,
volume: 24,
anno: 2001,
pagine: 991 - 1015
- SICI:
- 0114-5916(2001)24:13<991:TEITE->2.0.ZU;2-E
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- NEWLY-DIAGNOSED EPILEPSY; COMPLEX PARTIAL SEIZURES; ADD-ON THERAPY; PARTIAL-ONSET SEIZURES; SECONDARILY GENERALIZED SEIZURES; PREVIOUSLY UNTREATED EPILEPSY; MULTICENTER COMPARATIVE TRIAL; JUVENILE MYOCLONIC EPILEPSY; REFRACTORY PARTIAL EPILEPSY; CONTROLLED CLINICAL-TRIAL;
- Tipo documento:
- Review
- Natura:
- Periodico
- Settore Disciplinare:
- Clinical Medicine
- Citazioni:
- 223
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Arroyo, S Hosp Clin Barcelona, Unidad Epilepsia, Villarroel 170, E-08036 Barcelona, Spain Hosp Clin Barcelona Villarroel 170 Barcelona Spain E-08036pain
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- Citazione:
- S. Arroyo e G. Kramer, "Treating epilepsy in the elderly - Safety considerations", DRUG SAFETY, 24(13), 2001, pp. 991-1015
Abstract
The incidence of epilepsy increases with advancing age. Epilepsy in the elderly has different aetiologies from that in younger populations, cerebrovascular disease being the most common condition associated with seizures. Partial seizures are the predominant seizure type in older patients. A diagnosis of epilepsy in the elderly is based mainly on the history and is frequently delayed. In addition, seizure imitators are especially frequent. In many cases ancillary tests for diagnosis may show normal age-related variants, sometimes making results difficult to interpret. Treating epilepsy in theelderly is problematic due to a number of issues that relate to age and comorbidity. The physical changes associated with increasing age frequently lead to changes in the pharmacokinetics of many anticonvulsants. The treatment of epilepsy in the elderly is also complicated by the existence of otherdiseases that might affect the metabolism or excretion of anticonvulsants and the presence of concomitant medications that might interact with them. Moreover, specific trials of anticonvulsants in the aged population are scarce. General guidelines for treatment include starting at lower doses, slowing the titration schedule, individualising the choice or anticonvulsant tothe characteristics of the patient, avoiding anticonvulsants with important cognitive or sedative adverse effects, and where possible, treating with monotherapy.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:15:10