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Titolo:
Resistance of Helicobacter pylori to antibiotics and its impact on treatment options
Autore:
Megraud, F;
Indirizzi:
Hop Pellegrin, Bacteriol Lab, F-33076 Bordeaux, France Hop Pellegrin Bordeaux France F-33076 riol Lab, F-33076 Bordeaux, France
Titolo Testata:
DRUG RESISTANCE UPDATES
fascicolo: 3, volume: 4, anno: 2001,
pagine: 178 - 186
SICI:
1368-7646(200106)4:3<178:ROHPTA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
23S RIBOSOMAL-RNA; PENICILLIN-BINDING PROTEIN; METRONIDAZOLE RESISTANCE; CLARITHROMYCIN RESISTANCE; MACROLIDE RESISTANCE; RDXA GENE; AMOXICILLIN RESISTANCE; ERADICATION THERAPY; SEQUENCE-ANALYSIS; POINT MUTATIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Megraud, F Hop Pellegrin, Bacteriol Lab, Pl Amelie Raba Leon, F-33076 Bordeaux, France Hop Pellegrin Pl Amelie Raba Leon Bordeaux France F-33076 ance
Citazione:
F. Megraud, "Resistance of Helicobacter pylori to antibiotics and its impact on treatment options", DRUG RESIST, 4(3), 2001, pp. 178-186

Abstract

The treatment of Helicobacter pylori infection is jeopardized by resistance to the antibiotics used, which turns out to be the main risk factor for failure. Resistance is due to point mutations. For clarithromycin only two sites in the 23S rRNA sequence are concerned and can be easily detected by molecular methods, while for metronidazole several mutations on rdxA and other genes can be responsible and so do not allow such detection. The situation for the rare cases of amoxicillin resistance is not fully determined. The impact of resistance on the clinical outcome is dramatic for clarithromycin while it only decreases the success by 20% for metronidazole. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:33:03