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Titolo:
The apicoplast as an antimalarial drug target
Autore:
Ralph, SA; DOmbrain, MC; McFadden, GI;
Indirizzi:
Univ Melbourne, Sch Bot, Plant Cell Biol Res Ctr, Parkville, Vic 3010, Australia Univ Melbourne Parkville Vic Australia 3010 arkville, Vic 3010, Australia
Titolo Testata:
DRUG RESISTANCE UPDATES
fascicolo: 3, volume: 4, anno: 2001,
pagine: 145 - 151
SICI:
1368-7646(200106)4:3<145:TAAAAD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYL-COA CARBOXYLASE; PARASITE PLASMODIUM-FALCIPARUM; ORGANELLAR PROTEIN-SYNTHESIS; FATTY-ACID SYNTHESIS; TOXOPLASMA-GONDII; CRYPTOSPORIDIUM-PARVUM; MALARIAL PARASITE; IN-VITRO; APICOMPLEXAN PARASITES; RIBOSOMAL-RNA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: McFadden, GI Univ Melbourne, Sch Bot, Plant Cell Biol Res Ctr, Parkville, Vic 3010, Australia Univ Melbourne Parkville Vic Australia 3010 3010, Australia
Citazione:
S.A. Ralph et al., "The apicoplast as an antimalarial drug target", DRUG RESIST, 4(3), 2001, pp. 145-151

Abstract

Resistance to commonly used malaria drugs is spreading and new drugs are required urgently. The recent identification of a relict chloroplast (apicoplast) in malaria and related parasites offers numerous new targets for drugtherapy using well-characterized compounds. The apicoplast contains a range of metabolic pathways and housekeeping processes that differ radically tothose of the host thereby presenting ideal strategies for drug therapy. Indeed, many compounds targeting these plastid pathways are antimalarial and have favourable profiles based on extensive knowledge from their use as antibacterials. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:41:20