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Titolo:
Impairment of endothelial function after a high-fat meal in patients with coronary artery disease
Autore:
Zhao, SP; Liu, L; Gao, M; Zhou, QC; Li, YL; Xia, B;
Indirizzi:
Cent S Univ, Affiliated Hosp 2, Dept Cardiol, Changsha 410011, Peoples R China Cent S Univ Changsha Peoples R China 410011 gsha 410011, Peoples R China Cent S Univ, Affiliated Hosp 2, Dept Ultrasound, Changsha, Peoples R ChinaCent S Univ Changsha Peoples R China rasound, Changsha, Peoples R China Cent S Univ, Affiliated Hosp 2, Dept Nutr, Changsha, Peoples R China Cent S Univ Changsha Peoples R China pt Nutr, Changsha, Peoples R China
Titolo Testata:
CORONARY ARTERY DISEASE
fascicolo: 7, volume: 12, anno: 2001,
pagine: 561 - 565
SICI:
0954-6928(200111)12:7<561:IOEFAA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIGLYCERIDE-RICH LIPOPROTEINS; VASCULAR REACTIVITY; HEALTHY-SUBJECTS; HEART-DISEASE; RISK-FACTORS; CHOLESTEROL; REMNANTS; HUMANS; CHYLOMICRON; PROGRESSION;
Keywords:
triglyceride; high-fat meal; endothelium-dependent vasodilatation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Zhao, SP Cent S Univ, Affiliated Hosp 2, Dept Cardiol, Changsha 410011, Peoples R China Cent S Univ Changsha Peoples R China 410011 11, Peoples R China
Citazione:
S.P. Zhao et al., "Impairment of endothelial function after a high-fat meal in patients with coronary artery disease", CORON ART D, 12(7), 2001, pp. 561-565

Abstract

Objective To determine the effect of postprandial lipid changes on endothelial function in patients with coronary artery disease (CAD) after a high-fat meal. Methods We studied 50 CAD patients and 25 control participants, who were all normocholesterolemic. Flow-mediated vasodilatation of the brachial artery was evaluated by the high-resolution ultrasound technique before and after a single high-fat meal (800 calories; 50 g fat). Results Postprandial serum triglyceride level increased significantly at 2-7 h and mean flow-mediated vasodilatation was impaired significantly (from4.22 +/-0.44 to 2.75 +/-0.33%, P<0.01) for 75 subjects. The increment in 2h serum triglyceride level correlated positively with the decrement in postprandial flow-mediated vasodilatation (r=0.459, P<0.01). Postprandial triglyceride level was significantly higher in CAD patients than in control participants. Flow-mediated vasodilatation was significantly impaired in CAD patients (from 3.04 +/-0.39 to 1.69 +/-0.23%, P<0.01) and control participants (from 6.58<plus/minus>0.52 to 4.87 +/-0.19%, P<0.05) after a high-fat meal. The impairment of flow-mediated dilatation was more severe in CAD patients (44.41%) than in control participants (25.99%, P<0.01). Conclusion Postprandial endothelium-dependent vasodilatation after a single high-fat meal was severely impaired in normocholesterolemic CAD patients and control participants. The disordered postprandial metabolism of triglyceride-rich lipoproteins may play an atherogenic role by inducing endothelial dysfunction. Coronary Artery Dis 12:561-565 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 19/01/20 alle ore 11:34:06