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Titolo:
Cyclodiene organochlorine insecticide-induced alterations in the sulfur-redox cycle in CHO-K1 cells
Autore:
Bayoumi, AE; Garcia-Fernandez, AJ; Ordonez, C; Perez-Pertejo, Y; Cubria, JC; Reguera, RM; Balana-Fouce, R; Ordonez, D;
Indirizzi:
Univ Leon, INTOXCAL, Dept Farmacol & Toxicol, Leon 24071, Spain Univ LeonLeon Spain 24071 L, Dept Farmacol & Toxicol, Leon 24071, Spain Univ Aim Shams, Fac Agr, Dept Plant Protect, Cairo, Egypt Univ Aim Shams Cairo Egypt s, Fac Agr, Dept Plant Protect, Cairo, Egypt Univ Murcia, Dept Ciencias Socio Sanitarias, Murcia, Spain Univ Murcia Murcia Spain Dept Ciencias Socio Sanitarias, Murcia, Spain
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 3, volume: 130, anno: 2001,
pagine: 315 - 323
SICI:
1532-0456(200111)130:3<315:COIAIT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC LIPID-PEROXIDATION; HAMSTER OVARY CELLS; DNA-DAMAGE; PERITONEAL-MACROPHAGES; OXIDATIVE STRESS; GLUTATHIONE; TOXICITY; ENDRIN; PARAQUAT; RATS;
Keywords:
cyclodiene organochlorine insecticides; cytotoxicity; membrane permeability; sulfur-redox cycle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ordonez, D Univ Leon, INTOXCAL, Dept Farmacol & Toxicol, Campus Vegazana S-N, Leon 24071, Spain Univ Leon Campus Vegazana S-N Leon Spain 24071 on 24071, Spain
Citazione:
A.E. Bayoumi et al., "Cyclodiene organochlorine insecticide-induced alterations in the sulfur-redox cycle in CHO-K1 cells", COMP BIOC C, 130(3), 2001, pp. 315-323

Abstract

The effect of the cyclodiene organochlorine pesticides aldrin, dieldrin and endosulfan was assessed on CHO-KI cultures at fractions of their lethal doses, determined by the neutral red (NRI) incorporation assay (NRI6.25, NRI12.5 and NRI25). Glutathione peroxidase, reductase and S-transferase, and total and oxidised glutathione were evaluated along the standard growth curve of the cultures. After a 24-h incubation with each insecticide, glutathione peroxidase incurred a large increase, while glutathione, reductase and S-transferase activities were slightly higher than untreated controls. Unlike oxidised glutathione, the content of total glutathione declined significantly after exposure to cyclodiene insecticides. Changes in cell membrane integrity were assessed by the lactate dehydrogenase (LDH) release assay and lipid peroxidation for a wide range of pesticide concentrations. Membrane leakage and peroxide production were significantly enhanced at concentrations of aldrin and as low as 12.5 mug/ml, whereas dieldrin and endosulfan increased membrane fragility at much higher concentrations. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:22:20