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Titolo:
Compensatory changes in enzymes of arginine metabolism during renal hypertrophy in mice
Autore:
Natesan, S; Reddy, SRR;
Indirizzi:
Univ Pune, Dept Zool, Pune 411007, Maharashtra, India Univ Pune Pune Maharashtra India 411007 , Pune 411007, Maharashtra, India
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
fascicolo: 4, volume: 130, anno: 2001,
pagine: 585 - 595
SICI:
1096-4959(200112)130:4<585:CCIEOA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-KIDNEY; FUNCTIONAL-SIGNIFICANCE; IN-VIVO; LOCALIZATION; ORNITHINE; NEPHRON; MOUSE; UREA; TISSUES; PROTEIN;
Keywords:
arginine metabolism; compensatory changes in enzymes; nephrectomy; ornithine aminotransferase; proline synthesis; renal hypertrophy; transamidinase; urea cycle enzymes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Natesan, S Med Univ S Carolina, Dept Pathol & Lab Med, 165 Ashley Ave,POB 250908, Charleston, SC 29425 USA Med Univ S Carolina 165 Ashley Ave,POB 250908 Charleston SC USA 29425
Citazione:
S. Natesan e S.R.R. Reddy, "Compensatory changes in enzymes of arginine metabolism during renal hypertrophy in mice", COMP BIOC B, 130(4), 2001, pp. 585-595

Abstract

The present study investigates enzyme activities of the urea cycle, transamidinase and ornithine-proline inter-conversion in the hypertrophied kidneyafter unilateral nephrectomy in mice. Surgical removal of the left kidney in mice led to compensatory enlargement of the right kidney after 1 and 14 days. This renal growth was associated with an increase in glomerular volume (but not number) and enlargement of the proximal convoluted tubules. The total renal protein content increased in proportion to the increase in kidney weight, but the protein per gram weight of kidney did not change. The specific activity of only ornithine aminotransferase (OAT), the rate-limitingenzyme in the conversion of ornithine to proline, increased in 2 weeks of hypertrophy. The specific activity of all other enzymes was unchanged. However, the total enzyme activity per kidney of all the enzymes, without exception, was elevated in the hypertrophied kidney. While the increase in totalOAT activity was much more than the increase in kidney weight, all other enzymes increased more or less in proportion to the increase in renal mass. The results suggest that compensation in OAT activity to chronic reduction in renal mass was complete, but only partial in the case of other enzymes. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 18:00:28