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Titolo:
Immune reconstitution prevents continuous equine infectious anemia virus replication in an Arabian foal with severe combined immunodeficiency: Lessons for control of lentiviruses
Autore:
Mealey, RH; Fraser, DG; Oaks, JL; Cantor, GH; McGuire, TC;
Indirizzi:
Washington State Univ, Dept Vet Microbiol & Pathol, Pullman, WA 99164 USA Washington State Univ Pullman WA USA 99164 Pathol, Pullman, WA 99164 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 101, anno: 2001,
pagine: 237 - 247
SICI:
1521-6616(200111)101:2<237:IRPCEI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIC T-LYMPHOCYTES; BONE-MARROW; HORSES; EPITOPES; PROTEINS; VIREMIA; BLOOD; HEMATOPOIESIS; POLYMORPHISM; ALLOANTIGENS;
Keywords:
EIAV; lentivirus; equine; adoptive transfer; SCID; CTL; lymphocyte engraftment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Mealey, RH Washington State Univ, Dept Vet Microbiol & Pathol, Pullman, WA99164 USA Washington State Univ Pullman WA USA 99164 llman, WA 99164 USA
Citazione:
R.H. Mealey et al., "Immune reconstitution prevents continuous equine infectious anemia virus replication in an Arabian foal with severe combined immunodeficiency: Lessons for control of lentiviruses", CLIN IMMUNO, 101(2), 2001, pp. 237-247

Abstract

Acute infection with equine infectious anemia virus (EIAV), a lentivirus of horses, results in a persistent high-level viremia in Arabian foals affected with severe combined immunodeficiency (SCID). This observation argues against the idea that the transient nature of acute lentiviral viremia is solely a function of viral population dynamics. To extend these studies, EIAV-specific immune reconstitution was attempted prior to EIAV challenge in two SCID foals, using adoptively transferred virus-stimulated lymphocytes derived from persistently EIAV-infected half sibling donors. Following transfer, lymphocyte engraftment occurred in one foal, and EIAV-specific cytotoxicT lymphocytes as well as neutralizing antibody activity developed. Following a brief period of plasma viremia in this foal, EIAV replication was controlled and plasma virus could not be detected by RT-PCR or culture. These results provide further direct evidence that a specific immune response is required for termination of plasma viremia in acute lentiviral infections. (C) 2001 Academic Press.

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Documento generato il 22/01/20 alle ore 07:28:22