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Titolo:
Modulation of interleukin-15-induced human neutrophil responses by the plant lectin Viscum album agglutinin-I
Autore:
Pelletier, M; Lavastre, V; Savoie, A; Ratthe, C; Saller, R; Hostanska, K; Girard, D;
Indirizzi:
Univ Quebec, Inst Armand Frappier Sante Humaine, INRS, Pointe Claire, PQ H9R 1G6, Canada Univ Quebec Pointe Claire PQ Canada H9R 1G6 te Claire, PQ H9R 1G6, Canada Univ Zurich Hosp, Dept Internal Med, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 101, anno: 2001,
pagine: 229 - 236
SICI:
1521-6616(200111)101:2<229:MOIHNR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; GALACTOSIDE-SPECIFIC LECTIN; BLOOD MONONUCLEAR-CELLS; RHEUMATOID-ARTHRITIS; PROTEIN-SYNTHESIS; GENE-EXPRESSION; INDUCED APOPTOSIS; CANCER PATIENTS; IL-15; MISTLETOE;
Keywords:
neutrophil; interleukin-15; Viscum album; apoptosis; phagocytosis; protein synthesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Girard, D Univ Quebec, Inst Armand Frappier Sante Humaine, INRS, 245 Blvd Hymus, Pointe Claire, PQ H9R 1G6, Canada Univ Quebec 245 Blvd Hymus Pointe Claire PQ Canada H9R 1G6 anada
Citazione:
M. Pelletier et al., "Modulation of interleukin-15-induced human neutrophil responses by the plant lectin Viscum album agglutinin-I", CLIN IMMUNO, 101(2), 2001, pp. 229-236

Abstract

The plant lectin Viscum album agglutinin-I (VAA-I) and the interleukin-15 (IL-15) cytokine are two molecules with potential therapeutic properties known to modulate neutrophil functions when used separately. This study was conducted in order to better understand the mode of action of VAA-I and to elucidate how VAA-I could modulate IL-15-induced neutrophil responses. We found that VAA-I cannot induce phosphorylation events in human neutrophils. However, it enhances phagocytosis by itself without altering IL-15-induced phagocytosis. VAA-I was found to reverse the ability of IL-15 to delay neutrophil apoptosis and this was correlated with an inhibition of IL-15-inducedde novo protein synthesis. In addition, we also found that IL-15 cannot reverse or attenuate the caspase-induced gelsolin fragmentation observed during apoptosis as assessed by immunoblotting. We conclude that VAA-I can be used to modulate some, but not all, IL-15-induced neutrophil responses and that it acts independent of phosphorylation events. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:14:22