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Titolo:
Vaccination with allogeneic dendritic induces antitumor immunity in cells fused to carcinoma cells MUC1 transgenic mice
Autore:
Tanaka, Y; Koido, S; Chen, DS; Gendler, SJ; Kufe, D; Gong, JL;
Indirizzi:
Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA HarvardUniv Boston MA USA 02115 a Farber Canc Inst, Boston, MA 02115 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USAHarvard Univ Boston MA USA 02115 Deaconess Med Ctr, Boston, MA 02115 USA Mayo Clin, Scottsdale, AZ 85259 USA Mayo Clin Scottsdale AZ USA 85259Mayo Clin, Scottsdale, AZ 85259 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 101, anno: 2001,
pagine: 192 - 200
SICI:
1521-6616(200111)101:2<192:VWADIA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIC T-LYMPHOCYTES; IN-VITRO; ANTIGEN; GENERATION; RESPONSES; TOLERANCE; INDUCTION; PEPTIDE; GENE; VIVO;
Keywords:
allogeneic and syngeneic DC fusions; fusion cell vaccines; anti-tumor immunity; reversal of tolerance to MUC1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Gong, JL Harvard Univ, Sch Med, Dana Farber Canc Inst, 44 Binney St, Boston, MA 02115 USA Harvard Univ 44 Binney St Boston MA USA 02115 oston, MA 02115 USA
Citazione:
Y. Tanaka et al., "Vaccination with allogeneic dendritic induces antitumor immunity in cells fused to carcinoma cells MUC1 transgenic mice", CLIN IMMUNO, 101(2), 2001, pp. 192-200

Abstract

Fusions of autologous tumor cells with allogeneic dendritic cells (DC) represent an approach for the induction of antitumor immunity. In the present studies, we investigated the antitumor effects of vaccinating MUC1-transgenic (MUC1.Tg) mice with MC38/MUC1 carcinoma cells fused to allogeneic DC from BALB/c mice (allo-DC, H-2(d)) or syngeneic DC from C57BL/6 mice (syn-DC, H-2(b)). Both allo and syn fusion cells (FC/MUC1) expressed MHC class II, costimulatory molecules, and the MUC1 antigen. Allo-FC/MUC1 exhibited dual expression of MHC class I haplotypes (H-2(d)/H-2(b)) and MUC1 antigen. By contrast, only H-2(b) and MUC1 antigen were expressed by syn-FC/MUC1. CTLs from MUC1.Tg mice immunized with allo- or syn-FC/MUC1 fusion cells lysed MC38/MUC1 targets. Moreover, immunization with allo- or syn-FC/MUC1 was effective in eliminating established MUC1-positive pulmonary metastases in MUC1.Tgmice. These results indicate that immunization of MUC1.Tg mice with syn- or allo-FC/MUC1 is effective in reversing immunologic unresponsiveness to MUC1 antigen and inducing immunity against MUC1-positive tumors. The findingsin the present study have broader clinical implications for fusion cell vaccines. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 15:05:22