Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mechanisms of immune tolerance to food antigens in humans
Autore:
Zivny, JH; Moldoveanu, Z; Vu, HL; Russell, MW; Mestecky, J; Elson, CO;
Indirizzi:
Univ Alabama, Dept Med, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 , Dept Med, Birmingham, AL 35294 USA Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Microbiol, Birmingham, AL 35294 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 101, anno: 2001,
pagine: 158 - 168
SICI:
1521-6616(200111)101:2<158:MOITTF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANERGIC T-CELLS; MYELIN BASIC-PROTEIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ORAL TOLERANCE; CLONAL ANERGY; IN-VITRO; IMMUNOGLOBULIN-A; LYMPHOCYTES-T; II COLLAGEN; INDUCTION;
Keywords:
oral tolerance; food antigens; anergy; interleukin-2; humans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Zivny, JH Univ Alabama, Dept Med, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 , Birmingham, AL 35294 USA
Citazione:
J.H. Zivny et al., "Mechanisms of immune tolerance to food antigens in humans", CLIN IMMUNO, 101(2), 2001, pp. 158-168

Abstract

Immune responses and the mechanisms of tolerance to the common dietary antigens bovine gamma globulin (BGG), ovalbumin (OVA), and soybean protein were evaluated in normal human volunteers. Humoral and T cell proliferative responses to these antigens were measurable but low, consistent with immune tolerance. There were limited correlations between responses in the systemicand mucosal compartments, and in general the responses to one dietary antigen could not predict the response to another. T cell proliferation to dietary antigens increased significantly by addition of recombinant human interleukin-2 (rhuIL-2). Peripheral blood mononuclear cells stimulated with BGG or OVA expressed IEL-Ma chain but not IL-2 mRNA, consistent with T cell anergy. Incubation with exogenous IL-2 alone did not restore T cell proliferation to BGG or OVA. In some individuals T cell proliferation to an un elatedvaccine antigen was suppressed by addition of BGG or OVA, but could be reversed with low doses of rhuIL-2. We conclude that in humans anergy is the major mechanism of tolerance to chronic antigen feeding, and we propose thatsuch anergic, antigen-specific T cells actively contribute to maintenance of homeostasis in the intestine in the face of massive antigen challenge. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:21:06