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Titolo:
Overcoming original (antigenic) sin
Autore:
Anderson, DE; Carlos, MP; Nguyen, L; Torres, JV;
Indirizzi:
Univ Calif Davis, Sch Med Med Microbiol& Immunol, Davis, CA 95616 USA UnivCalif Davis Davis CA USA 95616 crobiol& Immunol, Davis, CA 95616 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 101, anno: 2001,
pagine: 152 - 157
SICI:
1521-6616(200111)101:2<152:OO(S>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY VIRUS-INFECTION; HIV-1/SIV CHIMERIC VIRUS; CD8(+) T-CELLS; ENVELOPE GLYCOPROTEIN; VIRAL-INFECTION; NEUTRALIZING ANTIBODIES; BYSTANDER ACTIVATION; VACCINATION; RESPONSES; CD4(+);
Keywords:
HIV; AIDS; vaccine; peptide; T cell; memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Anderson, DE Univ Calif Davis, Sch Med Med Microbiol& Immunol, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 nol, Davis, CA 95616 USA
Citazione:
D.E. Anderson et al., "Overcoming original (antigenic) sin", CLIN IMMUNO, 101(2), 2001, pp. 152-157

Abstract

Original antigenic sin describes a phenomenon in which the antibody response elicited in an individual after a secondary viral infection reacts more strongly to the viral variant that originally infected the individual. As Thelper cells play critical roles in promoting antibody responses, a similar phenomenon may hold true for T helper cell responses. This concept is particularly relevant to the development of vaccines. against viruses such as human immunodeficiency virus and hepatitis C virus, in which myriad viral variants are present throughout the human population. We have compared the effects of priming the immune system with a single peptide epitope or with acocktail of related peptides based on the epitope. Our data demonstrate that immunization with multiple peptide variants expands a more broadly reactive and durable T helper cell response than does immunization with a singlepeptide. This vaccine strategy may circumvent original antigenic sin. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:48:03