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Titolo:
Effects of gender and age on the cardiac baroreceptor reflex in hypertension
Autore:
Peckerman, A; Hurwitz, BE; Nagel, JH; Leitten, C; Agatston, AS; Schneiderman, N;
Indirizzi:
Mt Sinai Med Ctr, Noninvas Cardiol Lab, Miami Beach, FL 33140 USA Mt SinaiMed Ctr Miami Beach FL USA 33140 Lab, Miami Beach, FL 33140 USA Univ Stuttgart, D-7000 Stuttgart, Germany Univ Stuttgart Stuttgart Germany D-7000 tgart, D-7000 Stuttgart, Germany Univ Miami, Dept Psychol, Behav Med Res Ctr, Coral Gables, FL 33124 USA Univ Miami Coral Gables FL USA 33124 Res Ctr, Coral Gables, FL 33124 USA
Titolo Testata:
CLINICAL AND EXPERIMENTAL HYPERTENSION
fascicolo: 8, volume: 23, anno: 2001,
pagine: 645 - 656
SICI:
1064-1963(200111)23:8<645:EOGAAO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE VARIABILITY; HEART-RATE REFLEX; MENTAL STRESS; POSTMENOPAUSAL WOMEN; HEALTHY-SUBJECTS; SENSITIVITY; HUMANS; SEX; HEMODYNAMICS; PREVALENCE;
Keywords:
baroreceptor reflex sensitivity; baroreceptor reflex latency; hypertension; gender; age; phenylephrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Peckerman, A Vet Adm Med Ctr, Gulf War Res Ctr 127B, 385 Tremont Ave, E Orange, NJ 07019 USA Vet Adm Med Ctr 385 Tremont Ave E Orange NJ USA 07019 019 USA
Citazione:
A. Peckerman et al., "Effects of gender and age on the cardiac baroreceptor reflex in hypertension", CLIN EXP HY, 23(8), 2001, pp. 645-656

Abstract

The present study examined whether alterations in the cardiac baroreceptorreflex in hypertension may be a function of constitutional differences associated with gender and age. These hypotheses were tested using a cross-sectional design that compared 20 normotensive and 21 hypertensive men and women of varying age for differences in baroreceptor reflex sensitivity and response latency for heart rate, obtained using a modified bolus phenylephrine (Oxford) method. Relative to their respective normotensive controls, baroreceptor reflex sensitivity was reduced in hypertensive men, but not in hypertensive women. Among normotensive subjects, men had greater baroreceptor reflex sensitivitythan women. Independent from the effects associated with differences in blood pressure, age was not a significant predictor of reduction in baroreceptor reflex sensitivity. However, a combination of high blood pressure and older age was associated with a significant increase in baroreceptor reflex response time. In summary, gender and aging interacted with hypertension toalter two different aspects of the baroreceptor reflex. These results provide a preliminary indication that a decline in arterial baroreflex sensitivity may be more specific to hypertension in men than in women. Prolongationin baroreflex response latency in older hypertensive subjects also suggested that aging and hypertension may have a synergistic effect on cardiac parasympathetic function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:10:12