Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increased expression of biglycan mRNA in pressure-overloaded rat heart
Autore:
Ayada, Y; Kusachi, S; Murakami, T; Hirohata, S; Takemoto, S; Komatsubara, I; Hayashi, J; Iwabu, A; Ninomiya, Y; Tsuji, T;
Indirizzi:
Okayama Univ, Sch Med, Dept Internal Med 1, Okayama 7008558, Japan OkayamaUniv Okayama Japan 7008558 nternal Med 1, Okayama 7008558, Japan Okayama Univ, Sch Med, Dept Mol Biol & Biochem, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 iol & Biochem, Okayama 7008558, Japan Okayama Univ, Sch Med, Dept Med Technol, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 t Med Technol, Okayama 7008558, Japan
Titolo Testata:
CLINICAL AND EXPERIMENTAL HYPERTENSION
fascicolo: 8, volume: 23, anno: 2001,
pagine: 633 - 643
SICI:
1064-1963(200111)23:8<633:IEOBMI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL CARDIAC-HYPERTROPHY; GENE-EXPRESSION; EXTRACELLULAR-MATRIX; PROTEOGLYCANS BIGLYCAN; FIBRILLAR COLLAGEN; ANGIOTENSIN-II; GROWTH-FACTOR; DECORIN; LIVER; HYBRIDIZATION;
Keywords:
hypertension; extracellular matrix; proteoglycan; molecular biology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kusachi, S Okayama Univ, Sch Med, Dept Internal Med 1, 2-5-1,Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1,Shikata Cho Okayama Japan 7008558 58, Japan
Citazione:
Y. Ayada et al., "Increased expression of biglycan mRNA in pressure-overloaded rat heart", CLIN EXP HY, 23(8), 2001, pp. 633-643

Abstract

Biglycan mRNA expression in rat myocardium after abdominal aortic banding with renal ischemia was examined. The Northern blot analysis demonstrated that expression of biglycan mRNA in the pressure-overloaded hearts on days 2, 7, 14 and 28 was 2.88 +/-0.89, 2.32 +/-0.49, 2.17 +/-0.57 and 1.81 +/-0.46-fold higher, respectively, than that in the sham-operated hearts. In situhybridization showed an increased density of biglycan mRNA signal-positivecells in the pressure-overloaded hearts. The cells with positive signals were spindle-shaped mesenchymal cells in the myocardial interstitium. A marked increase in biglycan mRNA signal expression was also observed in endothelial cells and smooth muscle cells of the thickened myocardial capillary wall. These results demonstrated an increase in biglycan mRNA in the pressure-overloaded heart in mesenchymal cells in the myocardial interstitium, and in endothelial and smooth muscle cells of the capillaries, indicating that biglycan contributes to the ventricular and vascular remodeling in responseto pressure overload.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:44:44