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Titolo:
Endocranial vascular patterns in a familial rabbit model of coronal suturesynostosis
Autore:
Burrows, AM; OLoughlin, VD; Mooney, MP; Smith, TD; Losken, HW; Siegel, MI;
Indirizzi:
Slippery Rock Univ, Sch Phys Therapy, Slippery Rock, PA 16057 USA SlipperyRock Univ Slippery Rock PA USA 16057 Slippery Rock, PA 16057 USA Univ Pittsburgh, Dept Anthropol, Pittsburgh, PA 15260 USA Univ PittsburghPittsburgh PA USA 15260 thropol, Pittsburgh, PA 15260 USA Indiana Univ, Med Sci Program, Bloomington, IN USA Indiana Univ Bloomington IN USA iv, Med Sci Program, Bloomington, IN USA Univ Pittsburgh, Div Plast & Reconstruct Surg, Dept Oral Med & Pathol, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA Oral Med & Pathol, Pittsburgh, PA USA Univ Pittsburgh, Div Plast & Reconstruct Surg, Dept Anthropol, Pittsburgh,PA USA Univ Pittsburgh Pittsburgh PA USA urg, Dept Anthropol, Pittsburgh,PA USA Univ Pittsburgh, Div Plast & Reconstruct Surg, Dept Surg, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA ct Surg, Dept Surg, Pittsburgh, PA USA Univ Pittsburgh, Cleft Palate Craniofacial Ctr, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA e Craniofacial Ctr, Pittsburgh, PA USA Univ N Carolina, Charlotte, NC 28223 USA Univ N Carolina Charlotte NC USA28223 Carolina, Charlotte, NC 28223 USA Univ Pittsburgh, Dept Orthodont, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA gh, Dept Orthodont, Pittsburgh, PA USA
Titolo Testata:
CLEFT PALATE-CRANIOFACIAL JOURNAL
fascicolo: 6, volume: 38, anno: 2001,
pagine: 615 - 621
SICI:
1055-6656(200111)38:6<615:EVPIAF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCREASED INTRACRANIAL-PRESSURE; ARTIFICIAL CRANIAL DEFORMATION; FETAL HEAD CONSTRAINT; AGE-RELATED-CHANGES; CRANIOSYNOSTOTIC RABBITS; IN-VITRO; SINGLE-SUTURE; GROWTH-RATES; VOLUME; CRANIOSTENOSIS;
Keywords:
cerebrospinal fluid; coronal suture; craniosynostosis; dural venous sinus; endocranium; middle meningeal vessel;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Burrows, AM Slippery Rock Univ, Sch Phys Therapy, Suite 100 N Rd, SlipperyRock, PA 16057 USA Slippery Rock Univ Suite 100 N Rd Slippery Rock PA USA 16057 A
Citazione:
A.M. Burrows et al., "Endocranial vascular patterns in a familial rabbit model of coronal suturesynostosis", CLEF PAL-CR, 38(6), 2001, pp. 615-621

Abstract

Objective: The present study investigates the potential relationship between craniosynostosis and any changes in endocranial vasculature. The hypothesis that crania from rabbits with familial, nonsyndromic coronal suture synostosis and crania from rabbits with experimental immobilization of the coronal suture are associated with altered form of the middle meningeal vessels and dural venous sinuses is tested. Design: Silicone rubber endocasts from 14 adult New Zealand white rabbits (Oryctolagus cuniculus) with familial nonsyndromic coronal suture synostosis (five with bilateral coronal suture synostosis and nine with unilateral coronal suture synostosis) were made to assess middle meningeal vessel and dural venous sinus form. For comparative purposes, endocasts were made from 25 rabbits with normal, patent coronal sutures and 10 rabbits with experimental immobilization of the coronal suture. Impressions of the dural venous sinuses were assessed for depth and width. The area of the confluens of sinuses was also assessed. Impressions of the middle meningeal vessels were assessed for depth, width, and degree of convolution. For width of the dural venous sinuses and area of the confluens of sinuses, comparisons among groups were made with a one-way analysis of variance (ANOVA). For depth of the dural venous sinuses and impressions of the middle meningeal vessels, comparisons among groups were made using a Kruskal-Wallis one-way ANOVA. Results: Crania with familial coronal suture synostosis had significantly (p < .05) reduced posterior dural venous sinus dimensions when compared with both crania from rabbits with experimental immobilization of the coronal suture and rabbits with normal Corona[ sutures. Crania with both coronal suture synostosis and experimental immobilization had significant increases in dimensions of the middle meningeal vessels relative to normal crania. In addition, casts from rabbits with unicoronal suture synostosis showed marked asymmetry in the dural venous sinuses. Conclusions: These results support the hypothesis that craniosynostosis isassociated with alterations in endocranial vasculature. These changes are most likely a secondary response to synostosis rather than a causal factor and may reflect increased intracranial pressure, decreased intracranial volume, and local accumulations and reductions of cerebrospinal fluid in the posterior region of the skull and immediately deep to the coronal suture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:18:24