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Titolo:
Molecular cytogenetic analysis of a novel high-grade canine T-lymphoblastic lymphoma demonstrating co-expression of CD3 and CD79a cell markers
Autore:
Thomas, R; Smith, KC; Gould, R; Gower, SM; Binns, MM; Breen, M;
Indirizzi:
Anim Hlth Trust, Genet Sect, Newmarket CB8 7UU, Suffolk, England Anim HlthTrust Newmarket Suffolk England CB8 7UU 8 7UU, Suffolk, England Anim Hlth Trust, Pathol Sect, Newmarket CB8 7UU, Suffolk, England Anim Hlth Trust Newmarket Suffolk England CB8 7UU 8 7UU, Suffolk, England Aquarius Vet Ctr, Mildenhall IP28 7AL, Suffolk, England Aquarius Vet Ctr Mildenhall Suffolk England IP28 7AL AL, Suffolk, England
Titolo Testata:
CHROMOSOME RESEARCH
fascicolo: 8, volume: 9, anno: 2001,
pagine: 649 - 657
SICI:
0967-3849(2001)9:8<649:MCAOAN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE GENOMIC HYBRIDIZATION; SOLID TUMORS; DOG; CLASSIFICATION; FAMILIARIS; KARYOTYPE;
Keywords:
cancer; canine; comparative genomic hybridisation (CGH); dog; lymphoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Thomas, R Anim Hlth Trust, Genet Sect, Lanwades Pk, Newmarket CB8 7UU, Suffolk, England Anim Hlth Trust Lanwades Pk Newmarket Suffolk England CB8 7UUnd
Citazione:
R. Thomas et al., "Molecular cytogenetic analysis of a novel high-grade canine T-lymphoblastic lymphoma demonstrating co-expression of CD3 and CD79a cell markers", CHROMOS RES, 9(8), 2001, pp. 649-657

Abstract

We present the molecular cytogenetic analysis of a novel case of canine lymphoma, in a nine-year-old entire male collie cross retriever dog that presented with an enlarged prescapular lymph node. A diagnosis of high-grade lymphoblastic lymphoma was made by histological evaluation of fixed lymph node biopsy sections, whilst immunohistochemical analyses demonstrated co-expression of B- and T-cell antigens (CD79a and CD3) by 95% of lymphomatous cells. Comparative genomic hybridisation (CGH) analysis detected loss of dog chromosomes 11, 30 and 38 and gain of chromosome 36 within the lymphoma biopsy specimen. These findings correlated with direct cytogenetic analysis of tumour metaphases using whole chromosome paint probes representing each of these four chromosomes. This study represents the first report of the combined application of both direct and indirect cytogenetic techniques for the analysis of recurrent chromosome aberrations in canine cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 17:01:49