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Titolo:
Biodistribution of fullerene derivative C-60(OH)(x)(O)(y)
Autore:
Li, QN; Xiu, Y; Zhang, XD; Liu, RL; Du, QQ; Sun, AG; Chen, SL; Li, WX;
Indirizzi:
Chinese Acad Sci, Shanghai Inst Nucl Res, Shanghai 201800, Peoples R ChinaChinese Acad Sci Shanghai Peoples R China 201800 201800, Peoples R China Fudan Univ, Zhongshan Hosp, Dept Nucl Med, Shanghai 200032, Peoples R China Fudan Univ Shanghai Peoples R China 200032 nghai 200032, Peoples R China
Titolo Testata:
CHINESE SCIENCE BULLETIN
fascicolo: 19, volume: 46, anno: 2001,
pagine: 1615 - 1618
SICI:
1001-6538(200110)46:19<1615:BOFDC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; METALLOFULLERENE;
Keywords:
C60OH)(x)(O)(y); Te-99m-labeling; activity test; SPECT imaging; biodistribution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Li, QN Chinese Acad Sci, Shanghai Inst Nucl Res, Shanghai 201800, Peoples R China Chinese Acad Sci Shanghai Peoples R China 201800 Peoples R China
Citazione:
Q.N. Li et al., "Biodistribution of fullerene derivative C-60(OH)(x)(O)(y)", CHIN SCI B, 46(19), 2001, pp. 1615-1618

Abstract

The biological behavior of fullerene derivatives shows their considerable potential application in medicine field. To understand the biodistribution of C-60 derivatives as drugs or drug carriers, a simple water-soluble derivative C-60(OH)(x)(O)(y) was labeled with Te-99m. A gamma -counter and a single photo emission computed tomography (SPECT) were used to assess the biodistribution and metabolism of the labeled compound in mice and rabbits, respectively. The results showed that the compound could be absorbed rapidly by tissues, especially by coronal bone, breastbone, backbone, extremity honeycomb, liver and spleen. The clearance was slow from all tissues except forbrain. The compound might be excreted through urine and enteron. The biodistribution shows some difference from that of Yamago et al. In this note, we discuss the possible reason leading to the difference. Further study is needed to rind out to what extent the C60 itself determines the biodistribution of derivatives.

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Documento generato il 17/09/19 alle ore 18:32:01