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Titolo:
Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension
Autore:
Rubens, C; Ewert, R; Halank, M; Wensel, R; Orzechowski, HD; Schultheiss, HP; Hoeffken, G;
Indirizzi:
Free Univ Berlin, Benjamin Franklin Hosp, Dept Cardiol & Pulm, D-12200 Berlin, Germany Free Univ Berlin Berlin Germany D-12200 & Pulm, D-12200 Berlin, Germany Free Univ Berlin, Benjamin Franklin Hosp, Inst Clin Pharmacol & Toxicol, D-12200 Berlin, Germany Free Univ Berlin Berlin Germany D-12200 Toxicol, D-12200 Berlin, Germany German Heart Inst, Berlin, Germany German Heart Inst Berlin GermanyGerman Heart Inst, Berlin, Germany Univ Dresden, Carl Gustav Carus Hosp, Dept Internal Med & Pulm 1, Dresden,Germany Univ Dresden Dresden Germany ept Internal Med & Pulm 1, Dresden,Germany
Titolo Testata:
CHEST
fascicolo: 5, volume: 120, anno: 2001,
pagine: 1562 - 1569
SICI:
0012-3692(200111)120:5<1562:BEAEPL>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; HEART-FAILURE; GROWTH-FACTOR; CLEARANCE; EXPRESSION; PREVENTS; HYPOXIA; LUNGS; RATS;
Keywords:
endothelin; hemodynamics; primary pulmonary hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Rubens, C Free Univ Berlin, Benjamin Franklin Hosp, Dept Cardiol & Pulm, Hindenburgdamm 30, D-12200 Berlin, Germany Free Univ Berlin Hindenburgdamm 30 Berlin Germany D-12200 rmany
Citazione:
C. Rubens et al., "Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension", CHEST, 120(5), 2001, pp. 1562-1569

Abstract

Study objectives: Primary pulmonary hypertension (PPH) is a rare disease of unknown etiology that is characterized by a poor prognosis. This study was undertaken to investigate possible correlations between endothelin (ET)-1and big ET-1 plasma levels and the severity of PPH. Patients: Sixteen consecutive patients with PPH were included. Interventions: Hemodynamics of patients with PPH were measured by right-heart catheterization, and a 6-min walk test was performed. Measurements: Plasma levels of the biologically active peptide ET-1 and its precursor big ET-1 were determined in blood samples from the pulmonary artery, peripheral artery, and peripheral vein by radioimmunoassay. Results: A strong correlation was shown between pulmonary vascular resistance, mean pulmonary artery pressure, cardiac output, cardiac index, 6-min walk data, and elevated plasma levels of big ET-1 as well as mature ET-1 plasma levels at all sites of blood sampling (p<0.01 and p<0.05, respectively). Conclusions: Levels of circulating ET-1 might become a prognostic marker for patients with PPH and serve as a tool for the selection of patients who may benefit from treatment with ET-receptor antagonists.

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Documento generato il 01/12/20 alle ore 10:50:58