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Titolo:
Effect of DL-alpha-lipoic acid on mitochondrial enzymes in aged rats
Autore:
Arivazhagan, P; Ramanathan, K; Panneerselvam, C;
Indirizzi:
Univ Madras, Dr AL Mudaliar Post Grad Inst Basic Med Sci, Dept Biochem Med, Madras 600113, Tamil Nadu, India Univ Madras Madras Tamil Nadu India 600113 dras 600113, Tamil Nadu, India
Titolo Testata:
CHEMICO-BIOLOGICAL INTERACTIONS
fascicolo: 2, volume: 138, anno: 2001,
pagine: 189 - 198
SICI:
0009-2797(20011128)138:2<189:EODAOM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-TRANSPORT CHAIN; OXIDATIVE STRESS; GLUTATHIONE-REDUCTASE; METABOLIC ANTIOXIDANT; ASCORBIC-ACID; TRANSCRIPTION; HEPATOCYTES; DAMAGE; LIVER;
Keywords:
mitochondria; antioxidants; lipid peroxidation; ageing and DL-alpha-lipoic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Panneerselvam, C Univ Madras, Dr AL Mudaliar Post Grad Inst Basic Med Sci,Dept Biochem Med, Taramani Campus, Madras 600113, Tamil Nadu, India Univ Madras Taramani Campus Madras Tamil Nadu India 600113
Citazione:
P. Arivazhagan et al., "Effect of DL-alpha-lipoic acid on mitochondrial enzymes in aged rats", CHEM-BIO IN, 138(2), 2001, pp. 189-198

Abstract

Mitochondrial dysfunction appears to contribute to some of the loss of function accompanying ageing. Mitochondria from aged tissue use oxygen inefficiently impairing ATP synthesis and results in increased oxidant production. A high flux of oxidants not only damages mitochondria, but other importantcell biomolecules as wen. In the present investigation, the levels of lipid peroxidation, oxidized glutathione, non-enzymatic antioxidants and the activities of mitochondrial enzymes were measured in Ever and kidney mitochondria of young and aged rats before and after lipoic acid supplementation. In both liver and kidney increase in the levels of mitochondrial lipid peroxidation and oxidized glutathione and decrease in the levels of antioxidantsand the activities of mitochondrial enzymes were observed in aged rats. DL-alpha -lipoic acid supplemented aged rats showed a decrease in the levels of lipid peroxidation and oxidized glutathione and increase in the levels of reduced glutathione, vitamins C and E and the activities of mitochondrialenzymes like isocitrate dehydrogenase, alpha -ketoglutarate dehydrogenase,succinate dehydrogenase, NADH-dehydrogenase and cytochrome-c-oxidase. Thus, lipoic acid reverses the age-associated decline in endogenous low molecular weight antioxidants and mitochondrial enzymes and, therefore, may lower the increased risk of oxidative damage that occurs during ageing, From our results it can be concluded that lipoic acid supplementation enhances the activities of mitochondrial enzymes and antioxidant status and thereby protects mitochondria from ageing. (C) 2001 Published by Elsevier Science Ireland Ltd.

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Documento generato il 22/01/20 alle ore 06:57:44