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Titolo:
Thirty-five year mortality following receipt of SV40-contaminated polio vaccine during the neonatal period
Autore:
Carroll-Pankhurst, C; Engels, E; Strickler, HD; Goedert, JJ; Wagner, J; Mortimer, EA;
Indirizzi:
Case Western Reserve Univ, Mandel Sch Appl Social Sci, Cleveland, OH 44106USA Case Western Reserve Univ Cleveland OH USA 44106 , Cleveland, OH 44106USA NCI, Viral Epidemiol Branch, Rockville, MD 20852 USA NCI Rockville MD USA20852 iral Epidemiol Branch, Rockville, MD 20852 USA Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 9, volume: 85, anno: 2001,
pagine: 1295 - 1297
SICI:
0007-0920(20011102)85:9<1295:TYMFRO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN-TUMORS; PLEURAL MESOTHELIOMA; SIMIAN-VIRUS-40; CANCER; SV40; EXPOSURE; LYMPHOMA; RATES;
Keywords:
SV40; poliovirus vaccines; cancer; newborns;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Carroll-Pankhurst, C Case Western Reserve Univ, Mandel Sch Appl Social Sci, Cleveland, OH 44106USA Case Western Reserve Univ Cleveland OH USA 44106 USA
Citazione:
C. Carroll-Pankhurst et al., "Thirty-five year mortality following receipt of SV40-contaminated polio vaccine during the neonatal period", BR J CANC, 85(9), 2001, pp. 1295-1297

Abstract

Early poliovirus vaccines, both inactivated and live attenuated, were inadvertently contaminated with simian virus 40 (SV40), a monkey virus known tobe oncogenic for newborn hamsters. Although large epidemiologic studies have not identified an elevated cancer risk in persons who received SV40-contaminated vaccines, fragments of SV40 DNA have recently been identified in certain human tumours. We report the follow-up of a cohort of 1073 persons, unique because they received SV40-contaminated poliovirus vaccines as newborns in 1961-63. A previous report of the status of these subjects as of 1977-79 identified 15 deaths, none due to cancer. The present study utilized the National Death Index to identify deaths in the cohort for the years 1979-96. Expected deaths were calculated from Cleveland area sex-, age-, race- and year-specific mortality rates. Increased mortality from all causes was not found. 4 deaths from cancer were found compared to 3.16 expected (P = 0.77). However, 2 deaths from testicular cancer occurred, compared to 0.05 expected (P = 0.002), which may be a chance finding due to multiple comparisons. There were 2 deaths due to leukaemia, at non-significant finding, and no deaths due to tumours of the types putatively associated with SV40. Although these results are, for the most part, consistent with other negative epidemiologic investigations of risks from SV40-contaminated vaccines, further study of testicular cancer may be warranted, and it will be important tocontinue monitoring this cohort which is now reaching middle-age. (C) 2001Cancer Research Campaign.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:24:47