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Titolo:
Chemistry of zinc(II) fluorophore sensors
Autore:
Kimura, E; Aoki, S;
Indirizzi:
Hiroshima Univ, Fac Med, Dept Med Chem, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan
Titolo Testata:
BIOMETALS
fascicolo: 3-4, volume: 14, anno: 2001,
pagine: 191 - 204
SICI:
0966-0844(200109)14:3-4<191:COZFS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PENDANT MACROCYCLIC TETRAAMINE; HIGHLY SELECTIVE RECOGNITION; AQUEOUS-SOLUTION; CARBONIC-ANHYDRASE; FLUORESCENT-PROBE; DIVALENT ZINC; BIOMIMETIC ZINC(II)-FLUOROPHORE; POLYAMINE COMPLEXES; FINGER DOMAINS; THYMINE BASE;
Keywords:
carbonic anhydrase; fluorophore; macrocyclic polyamine; sensor; sulfonamide; zinc; zinquin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Kimura, E Hiroshima Univ, Fac Med, Dept Med Chem, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 iroshima 7348551, Japan
Citazione:
E. Kimura e S. Aoki, "Chemistry of zinc(II) fluorophore sensors", BIOMETALS, 14(3-4), 2001, pp. 191-204

Abstract

The biological role of the zinc(II) ion has been recognized in DNA and RNAsynthesis, apoptosis, gene expression, or protein structure and function. Therefore, development of useful zinc(II) sensors has recently been attracting much interest. Chemistry for selective and efficient detection of traceZn2+ is a central issue. Recently, various types of zinc-fluorophores are emerging, comprising bio-inspired aromatic sulfonamide derivatives, zinc-finger peptides attached to fluorescent dyes, or fluorophore-pendant macrocyclic polyamines. The chemical principles, properties and limitations of these Zn2+-fluorophores are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 04:42:34