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Titolo:
Long-term follow-up of recipients of CD8-depleted donor lymphocyte infusions for the treatment of chronic myelogenous leukemia relapsing after allogeneic progenitor cell transplantation
Autore:
Shimoni, A; Gajewski, J; Donato, M; Martin, T; OBrien, S; Talpaz, M; Cohen, A; Korbling, M; Champlin, R; Giralt, S;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Blood & Bone Marrow Transplnatat, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 arrow Transplnatat, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Ctr, Dept Leukemia, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Bioimmunotherapy, Houston, TX 77030USA Univ Texas Houston TX USA 77030 pt Bioimmunotherapy, Houston, TX 77030USA
Titolo Testata:
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
fascicolo: 10, volume: 7, anno: 2001,
pagine: 568 - 575
SICI:
1083-8791(2001)7:10<568:LFOROC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; CHRONIC MYELOID-LEUKEMIA; VERSUS-HOST DISEASE; CYTOTOXIC T-LYMPHOCYTES; LEUKOCYTE INFUSIONS; ADOPTIVE IMMUNOTHERAPY; SELECTIVE DEPLETION; ACUTE GVHD; GRAFT; TRANSFUSIONS;
Keywords:
chronic myeloid leukemia; donor lymphocyte infusion; graft-versus-host disease; CD8 depletion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Giralt, S Univ Texas, MD Anderson Canc Ctr, Dept Blood & Bone Marrow Transplnatat, 1515 Holcombe Blvd,Box 423, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd,Box 423 Houston TX USA 77030 0 USA
Citazione:
A. Shimoni et al., "Long-term follow-up of recipients of CD8-depleted donor lymphocyte infusions for the treatment of chronic myelogenous leukemia relapsing after allogeneic progenitor cell transplantation", BIOL BLOOD, 7(10), 2001, pp. 568-575

Abstract

Donor lymphocyte infusions (DLIs) are an effective treatment for relapsed Chronic myeloid leukemia (CML) after allogeneic transplantation but are limited by the occurrence of GVHD. CD8(+)T lymphocytes are involved in the pathogenesis of GVHD but may not be essential for the graft-versus-leukemia (GVL) effect in CML. We have treated 26 CML patients with posttransplantationrelapse with CDS-depleted DLI. Thirteen of 15 patients (87%) who relapsed in early-phase CML achieved complete cytogenetic response, but only 1 of 11who relapsed in advanced-phase disease achieved complete response. Acute GVHD occurred in 2 patients (8%), and extensive chronic GVHD occurred in 2 patients (11%). Treatment-related mortality was 11.5%. Responses were durable; with a median follow-up of 4.2 years (1-7.5 years), only 1 responding patient relapsed (7%). CD8-depleted DLI was equally effective and safe after unrelated donor transplants and sibling transplants. Cytogenetic clonal evolution at the time of DLI was not predictive of treatment failure unless associated with hematologic criteria for disease acceleration. CD8 depletion is an effective method to separate GVL from GVHD for posttransplantation relapsed CML. This strategy is associated with durable complete remissions and a low rate of complications and therefore merits further investigation inlarger-scale comparative trials.

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Documento generato il 05/12/20 alle ore 01:09:25