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Titolo:
AIB1, A STEROID-RECEPTOR COACTIVATOR AMPLIFIED IN BREAST AND OVARIAN-CANCER
Autore:
ANZICK SL; KONONEN J; WALKER RL; AZORSA DO; TANNER MM; GUAN XY; SAUTER G; KALLIONIEMI OP; TRENT JM; MELTZER PS;
Indirizzi:
NATL HUMAN GENOME RES INST,CANC GENET LAB,NIH BETHESDA MD 20892 NATL HUMAN GENOME RES INST,CANC GENET LAB,NIH BETHESDA MD 20892 UNIV TAMPERE,INST MED TECHNOL,CANC GENET LAB FIN-33101 TAMPERE FINLAND TAMPERE UNIV HOSP FIN-33101 TAMPERE FINLAND UNIV BASEL,INST PATHOL CH-4003 BASEL SWITZERLAND
Titolo Testata:
Science
fascicolo: 5328, volume: 277, anno: 1997,
pagine: 965 - 968
SICI:
0036-8075(1997)277:5328<965:AASCAI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE GENOMIC HYBRIDIZATION; AMPLIFICATION; SEQUENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Anzick et al., "AIB1, A STEROID-RECEPTOR COACTIVATOR AMPLIFIED IN BREAST AND OVARIAN-CANCER", Science, 277(5328), 1997, pp. 965-968

Abstract

Members of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand-dependent transcription. AIB1, a member of the SRC-1 family, was clonedduring a search on the long arm of chromosome 20 for genes whose expression and copy number were elevated in human breast cancers. AIB1 amplification and overexpression were observed in four of five estrogen receptor-positive breast and ovarian cancer cell lines. Subsequent evaluation of 105 unselected specimens of primary breast cancer found AIB1amplification in approximately 10 percent and high expression in 64 percent of the primary tumors analyzed. AIB1 protein interacted with estrogen receptors in a ligand-dependent fashion, and transfection of AIB1 resulted in enhancement of estrogen-dependent transcription, These observations identify AIB1 as a nuclear receptor coactivator whose altered expression may contribute to development of steroid-dependent cancers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:18:45