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Titolo:
Downregulation of repressive CUP/AP-2 isoforms during adipocyte differentiation
Autore:
Holt, EH; Lane, MD;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA JohnsHopkins Univ Baltimore MD USA 21205 l Chem, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 pt Med, Baltimore, MD 21205 USA
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 4, volume: 288, anno: 2001,
pagine: 752 - 756
SICI:
0006-291X(20011109)288:4<752:DORCID>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR AP-2; BINDING-PROTEIN-ALPHA; 3T3-L1 PREADIPOCYTES; GENE-EXPRESSION; MURINE EMBRYOGENESIS; ACTIVATION; ADIPOGENESIS; PROMOTER; ACID; AP-2-ALPHA;
Keywords:
CCAAT enhancer binding protein (C/EBP); 3T3-L1 preadipocytes; C/EBP alpha undifferentiated protein (CUP);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Holt, EH Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 altimore, MD 21205 USA
Citazione:
E.H. Holt e M.D. Lane, "Downregulation of repressive CUP/AP-2 isoforms during adipocyte differentiation", BIOC BIOP R, 288(4), 2001, pp. 752-756

Abstract

Activation of transcription of the C/EBP alpha (CCAAT/enhancer binding protein a) gene is a critical event in the differentiation of 3T3-L1 preadipocytes into adipocytes. The kinetics of this process parallels a decline of AP-2 alpha protein (also referred to as CUP, C/EBP undifferentiated protein)and decreased binding of CUP/AP-2 alpha to the C/EBP alpha promoter. Mutation of the CUP/AP-2 binding sites in the C/EBPa promoter results in increased C/EBPa expression. Based on these findings, it appears that decline in AP-2a expression is an important early event in the adipocyte differentiation program. In the studies presented here, we identify three mRNAs that encode the repressive CLTP/AP-2 alpha isoforms expressed in undifferentiated 3T3-L1 preadipocytes. We demonstrate that the kinetics of the decline of these isoforms' expression over the course of differentiation parallels both the decrease in CUP/AP-2 alpha DNA binding activity and the increase in C/EBPalpha protein observed in previous studies. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:26:35