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Titolo:
Conditioned taste aversion as a learning and memory paradigm
Autore:
Welzl, H; DAdamo, P; Lipp, HP;
Indirizzi:
Univ Zurich, Inst Anat, Div Neuroanat & Behav, CH-8057 Zurich, SwitzerlandUniv Zurich Zurich Switzerland CH-8057 ehav, CH-8057 Zurich, Switzerland IGBE, CNR, I-27100 Pavia, Italy IGBE Pavia Italy I-27100IGBE, CNR, I-27100 Pavia, Italy
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 125, anno: 2001,
pagine: 205 - 213
SICI:
0166-4328(20011101)125:1-2<205:CTAAAL>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS INDUCTION; PROTEIN-KINASE-C; NUCLEUS BASALIS MAGNOCELLULARIS; BASOLATERAL AMYGDALA LESIONS; DORSAL HIPPOCAMPAL-LESIONS; INSULAR CORTEX DISRUPTS; IMMEDIATE-EARLY GENES; SINGLE-LOCUS CONTROL; 3 DIFFERENT STRAINS; LATENT INHIBITION;
Keywords:
transgenic mice; knockout; method; behavioral phenotyping;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
140
Recensione:
Indirizzi per estratti:
Indirizzo: Welzl, H Univ Zurich, Inst Anat, Div Neuroanat & Behav, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 8057 Zurich, Switzerland
Citazione:
H. Welzl et al., "Conditioned taste aversion as a learning and memory paradigm", BEH BRA RES, 125(1-2), 2001, pp. 205-213

Abstract

Conditioned taste aversion (CTA) is a well established learning and memoryparadigm in rats and mice that is considered to be a special form of classical conditioning. Rodents - as well as many other species including man - learn to associate a novel taste (CS) with nausea (US), and as a consequence avoid drinking fluid with this specific taste. In contrast to other typesof classical conditioning, even CS-US intervals lasting several hours leadto an aversion to the gustatory CS. With increasing CS-US delay duration. however. the aversion against the CS gradually decreases. Mice differ from rats in their reaction to the CS as well as the US. They tolerate a much higher concentration of saccharin and they do not show any clear signs of nausea when injected with the US. Advantages of this task are its relative independence of motor behavior, well described pathways for the CS and partly the US, and the wealth of available anatomical and pharmacological data implying several brain structures (e.g. parabrachial nucleus, amygdala, insular cortex), neurotransmitters and their receptors (e.g. cholinergic system, NMDA-receptors), and cellular processes (e.g. expression of immediate earlygenes, Ras-MAP kinase signaling pathway, CREB phosphorilation, protein tyrosine phosphorilation, protein synthesis) in CTA. The CTA paradigm has alsobeen successfully used to phenotype mouse mutants. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:20:36