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Titolo:
Motor performance and regional brain metabolism of spontaneous murine mutations with cerebellar atrophy
Autore:
Lalonde, R; Strazielle, C;
Indirizzi:
Univ Rouen, Fac Sci, Lab Neurobiol Apprentissage, UPRES PSY COEA 1780, F-76821 Mont St Aignan, France Univ Rouen Mont St Aignan France F-76821 F-76821 Mont St Aignan, France CHU Montreal, Serv Neurol, Hotel Dieu, Montreal, PQ H2W 1T8, Canada CHU Montreal Montreal PQ Canada H2W 1T8 ieu, Montreal, PQ H2W 1T8, Canada Univ Nancy 1, Lab Microscopie Elect, Fac Med, F-54500 Vandoeuvre Les Nancy, France Univ Nancy 1 Vandoeuvre Les Nancy France F-54500 euvre Les Nancy, France
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 125, anno: 2001,
pagine: 103 - 108
SICI:
0166-4328(20011101)125:1-2<103:MPARBM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LURCHER MUTANT MICE; CYTOCHROME-OXIDASE ACTIVITY; RECEPTOR ROR-ALPHA; GLUTAMIC-ACID DECARBOXYLASE; CHANNEL DELTA-2 SUBUNIT; ORPHAN NUCLEAR RECEPTOR; PURKINJE-CELLS; SPONTANEOUS-ALTERNATION; DIFFERENTIAL ROLES; STAGGERER MOUSE;
Keywords:
cerebellum; motor coordination; equilibrium; cytochrome oxidase; regional brain metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Lalonde, R Univ Rouen, Fac Sci, Lab Neurobiol Apprentissage, UPRES PSY COEA 1780, F-76821 Mont St Aignan, France Univ Rouen Mont St Aignan France F-76821 nt St Aignan, France
Citazione:
R. Lalonde e C. Strazielle, "Motor performance and regional brain metabolism of spontaneous murine mutations with cerebellar atrophy", BEH BRA RES, 125(1-2), 2001, pp. 103-108

Abstract

Three spontaneous mutations with cerebellar atrophy were evaluated for motor coordination and regional brain metabolism, as assessed by cytochrome oxidase (CO) activity. Despite similar neuropathological characteristics, thebehavioral phenotype of Lurcher is less severe than that of staggerer, possibly caused by the slower onset of their neuronal degeneration. Although fewer cerebellar cells degenerate in hot-foot than in Lurcher, their motor deficits are more severe, indicating the presence of dysfunctional cells. COactivity in the deep cerebellar nuclei was increased in Lurcher and staggerer but unchanged in hot-foot, probably due to the severe loss of GABAergicinput from Purkinje cells in the first two mutants but not the third. Altered CO activity in cerebellar-related pathways was linearly correlated withmotor performance, indicating that the activity of this enzyme is associated not only with neuronal activity but also with motor performance. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:23:05