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Titolo:
Measuring pain in the (knockout) mouse: big challenges in a small mammal
Autore:
Wilson, SG; Mogil, JS;
Indirizzi:
Univ Illinois, Dept Psychol, Champaign, IL 61820 USA Univ Illinois Champaign IL USA 61820 ept Psychol, Champaign, IL 61820 USA Univ Illinois, Neurosci Program, Champaign, IL 61820 USA Univ Illinois Champaign IL USA 61820 sci Program, Champaign, IL 61820 USA
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 125, anno: 2001,
pagine: 65 - 73
SICI:
0166-4328(20011101)125:1-2<65:MPIT(M>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORPHINE-INDUCED ANALGESIA; SUPRASPINAL ORPHANIN FQ/NOCICEPTIN; HOT-PLATE; FORMALIN TEST; MICE LACKING; BEHAVIORAL CHARACTERIZATION; INDIVIDUAL-DIFFERENCES; NOCICEPTIVE RESPONSES; INDUCED POTENTIATION; BACKGROUND GENOTYPE;
Keywords:
mice; pain; algesiometry; species differences; strain differences; transgenic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Mogil, JS Univ Illinois, Dept Psychol, 603 E Daniel St, Champaign, IL 61820 USA Univ Illinois 603 E Daniel St Champaign IL USA 61820 L 61820 USA
Citazione:
S.G. Wilson e J.S. Mogil, "Measuring pain in the (knockout) mouse: big challenges in a small mammal", BEH BRA RES, 125(1-2), 2001, pp. 65-73

Abstract

The increasing popularity of the mouse as a subject in basic science studies of pain can largely be attributed to the development of transgenic 'knockout' technology in this species only. To take advantage of this biologicaltechnique, many investigators are rushing to adapt to the mouse experimental protocols that were designed for the rat. However. the myriad physiological and behavioral differences between these two rodent species render suchadaptations non-trivial and in many cases seriously problematic. Tn this article we review the basic nociceptive assays used in behavioral pain research (thermal, mechanical, electrical and chemical), and highlight how species differences affect their proper application. In addition. some of the issues specifically pertaining to the interpretation of such data in knockoutstudies are addressed. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:53:16