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Titolo:
Leptin in septic arthritis: decreased levels during infection and amelioration of disease activity upon its administration
Autore:
Hultgren, OH; Tarkowski, A;
Indirizzi:
Gothenburg Univ, Dept Rheumatol, S-41346 Gothenburg, Sweden Gothenburg Univ Gothenburg Sweden S-41346 ol, S-41346 Gothenburg, Sweden
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 6, volume: 3, anno: 2001,
pagine: 389 - 394
SICI:
1465-9913(2001)3:6<389:LISADL>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; OB/OB MICE; OBESE GENE; STAPHYLOCOCCUS-AUREUS; RHEUMATOID-ARTHRITIS; IMMUNE-RESPONSE; FACTOR-ALPHA; MOUSE; DEFICIENCY; EXPRESSION;
Keywords:
arthritis; interleukin-6; leptin; Staphylococcus aureus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Hultgren, OH Gothenburg Univ, Dept Rheumatol, Guldhedsgatan 10A, S-41346 Gothenburg, Sweden Gothenburg Univ Guldhedsgatan 10A Gothenburg Sweden S-41346
Citazione:
O.H. Hultgren e A. Tarkowski, "Leptin in septic arthritis: decreased levels during infection and amelioration of disease activity upon its administration", ARTHRITIS R, 3(6), 2001, pp. 389-394

Abstract

Weight loss is typically found during severe infections, e.g. septic arthritis. The aim of our study was to evaluate the role of leptin, regulator offood intake and energy expenditure, for the development of Staphylococcus aureus-triggered arthritis. Leptin production was found to be decreased during murine S. aureus-induced arthritis. Treatment with recombinant leptin neither restored the basal leptin levels nor affected the weight loss duringthe disease, but it significantly decreased the severity of septic arthritis. Exogenous leptin did not affect the staphylococcal load as measured in blood, joints and kidneys. Preceding the effects on joint manifestations, serum levels of interleukin-6 decreased in leptin-treated mice. In conclusion, the treatment with recombinant leptin reduced both the severity of jointmanifestations in S. aureus-induced arthritis and the inflammatory response, as measured by serum IL-6 levels, without affecting the survival of bacteria in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 19:18:12