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Titolo:
High frequency of association of rheumatic/autoimmune diseases and untreated male hypogonadism with severe testicular dysfunction
Autore:
Jimenez-Balderas, FJ; Tapia-Serrano, R; Fonseca, ME; Arellano, J; Beltran, A; Yanez, P; Camargo-Coronel, A; Fraga, A;
Indirizzi:
Ctr Med Nacl SXXI IMSS, Hosp Especialidades, Dept Reumatol, Mexico City, DF, Mexico Ctr Med Nacl SXXI IMSS Mexico City DF Mexico ol, Mexico City, DF, Mexico Ctr Med Nacl SXXI IMSS, Hosp Especialidades, Secc Androl, Mexico City, DF,Mexico Ctr Med Nacl SXXI IMSS Mexico City DF Mexico rol, Mexico City, DF,Mexico Ctr Med Nacl SXXI IMSS, Hosp Especialidades, Lab Hormonas, Mexico City, DF, Mexico Ctr Med Nacl SXXI IMSS Mexico City DF Mexico as, Mexico City, DF, Mexico Ctr Med Nacl SXXI IMSS, Hosp Ped, Unidad Invest Med Inmunol, Mexico City, DF, Mexico Ctr Med Nacl SXXI IMSS Mexico City DF Mexico ol, Mexico City, DF, Mexico
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 6, volume: 3, anno: 2001,
pagine: 362 - 367
SICI:
1465-9913(2001)3:6<362:HFOAOR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; KLINEFELTERS-SYNDROME; RHEUMATOID-ARTHRITIS; IMMUNOLOGICAL FEATURES; ESTROGEN METABOLISM; SCLERODERMA; ANDROGEN; THERAPY;
Keywords:
ankylosing spondylitis; hypogonadism; rheumatic diseases; systemic lupus erythematosus; testosterone;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Jimenez-Balderas, FJ Pregonero 161,Col Fraccionamiento Colina Sur, Mexico City 01430, DF, Mexico Pregonero 161,Col Fraccionamiento Colina Sur MexicoCity DF Mexico 01430
Citazione:
F.J. Jimenez-Balderas et al., "High frequency of association of rheumatic/autoimmune diseases and untreated male hypogonadism with severe testicular dysfunction", ARTHRITIS R, 3(6), 2001, pp. 362-367

Abstract

Our goal in the present work was to determine whether male patients with untreated hypogonadism have an increased risk of developing rheumatic/autoimmune disease (RAD), and, if so, whether there is a relation to the type of hypogonadism. We carried out neuroendocrine, genetic, and rheumatologic investigations in 13 such patients and 10 healthy male 46,XY normogonadic control subjects. Age and body mass index were similar in the two groups. Nine of the 13 patients had hypergonadotropic hypogonadism (five of whom had Klinefelter's syndrome [karyotype 47,XXY]) and 4 of the 13 had hypogonadotropic hypogonadism (46,XY), Of these last four, two had Kallmann's syndrome andtwo had idiopathic cryptorchidism. Eight (61%) of the 13 patients studied had RADs unrelated to the etiology of their hypogonadism. Of these, four had ankylosing spondylitis and histocompatibility, B27 antigen, two had systemic lupus erythematosus (in one case associated with antiphospholipids), one had juvenile rheumatoid arthritis, and one had juvenile dermatomyositis. In comparison with the low frequencies of RADs in the general population (about 0.83%, including systemic lupus erythematosus, 0.03%; dermatomyositis, 0.04%; juvenile rheumatoid arthritis, 0.03%; ankylosing spondylitis, 0.01%; rheumatoid arthritis, 0.62%; and other RAID, 0.1%), there were surprisingly high frequencies of such disorders in this small group of patients with untreated hypogonadism (P < 0.001) and very low serum testosterone levels (P = 0.0005). The presence of RADs in these patients was independent of the etiology of their hypogonadism and was associated with marked gonadal failure with very low testosterone levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:27:16