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Titolo:
Articular cartilage and changes in arthritis - Noncollagenous proteins andproteoglycans in the extracellular matrix of cartilage
Autore:
Roughley, PJ;
Indirizzi:
Shriners Hosp Children, Genet Unit, Montreal, PQ H3G 1A6, Canada Shriners Hosp Children Montreal PQ Canada H3G 1A6 eal, PQ H3G 1A6, Canada
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 6, volume: 3, anno: 2001,
pagine: 342 - 347
SICI:
1465-9913(2001)3:6<342:ACACIA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASEMENT-MEMBRANES; LINK PROTEIN; SULFATE PROTEOGLYCAN; TARGETED DISRUPTION; CHROMOSOME LOCATION; SKIN FRAGILITY; AGGRECAN; GENE; FIBRONECTIN; MICE;
Keywords:
cartilage; extracellular matrix; protein; proteoglycan;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Roughley, PJ Shriners Hosp Children, Genet Unit, 1529 Cedar Ave, Montreal,PQ H3G 1A6, Canada Shriners Hosp Children 1529 Cedar Ave Montreal PQ Canada H3G 1A6
Citazione:
P.J. Roughley, "Articular cartilage and changes in arthritis - Noncollagenous proteins andproteoglycans in the extracellular matrix of cartilage", ARTHRITIS R, 3(6), 2001, pp. 342-347

Abstract

Cartilage contains numerous noncollagenous proteins in its extracellular matrix, including proteoglycans. At least 40 such molecules have been identified, differing greatly in structure, distribution, and function. Some are present in only selected cartilages or cartilage zones, some vary in their presence with a person's development and age, and others are more universalin their expression. Some may not even be made by the chondrocytes, but may arise by absorption from the synovial fluid. In many cases, the molecules' function is unclear, but the importance of others is illustrated by theirinvolvement in genetic disorders. This review provides a selective survey of these molecules and discusses their structure, function, and involvementin inherited and arthritic disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:42:05