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Titolo:
Effects of sub-chronic in vivo chlorpyrifos exposure on muscarinic receptors and adenylate cyclase of rat striatum
Autore:
Huff, RA; Abu-Qare, AW; Abou-Donia, MB;
Indirizzi:
Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Pharmacol & Canc Biol, Durham, NC 27710 USA
Titolo Testata:
ARCHIVES OF TOXICOLOGY
fascicolo: 8, volume: 75, anno: 2001,
pagine: 480 - 486
SICI:
0340-5761(200110)75:8<480:EOSIVC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC CHOLINESTERASE INHIBITION; ACETYLCHOLINE-RECEPTOR; HIGH-AFFINITY; ORAL CHLORPYRIFOS; ADULT-RATS; DIFFERENTIAL REGULATION; CHOLINERGIC RECEPTORS; CIS-METHYLDIOXOLANE; BINDING-PROPERTIES; SIGNALING CASCADE;
Keywords:
organophosphates; cholinesterase; insecticide; chlorpyrifos;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Abou-Donia, MB Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 c Biol, Durham, NC 27710 USA
Citazione:
R.A. Huff et al., "Effects of sub-chronic in vivo chlorpyrifos exposure on muscarinic receptors and adenylate cyclase of rat striatum", ARCH TOXIC, 75(8), 2001, pp. 480-486

Abstract

In this study dosing regimens were designed such that cholinesterase inhibition following exposure to chlorpyrifos was produced in one treatment group. but was absent in the other. The higher dosing regimen inhibited plasma and brain cholinesterase activities by 51 and 70%, respectively, and resulted in decreased [H-3]cis-methyldioxolane ([H-3]CD) binding, which was attributable to a decrease in B-max. No concomitant loss Of [H-3]quinuclidinyl benzilate ([H-3]QNB) binding sites was observed., indicating that the M, muscarinic receptor subtype to which [H-3]CD binds is particularly susceptibleto alterations induced by chlorpyrifos treatment. As the M-2 receptor subtype is surmised to be the muscarinic autoreceptor, decreases in this receptor may exacerbate poisoning by organophosphorus agents as a result of decreased ability to terminate synaptic acetylcholine release. The ability of carbachol to inhibit striatal adenylate cyclase, which is an effector molecule associated with the M-2 receptor., was unaltered in chlorpyrifos-treated rats. Decreases in M-2 receptors occurred with the higher dosing regimen, in the absence of any clinical manifestations. Thus, in the absence of overtclinical signs, perturbations of the muscarinic receptor system did occur as a result of sub-chronic chlorpyrifos exposure. Such alterations may contribute to neurological impairments that develop following chronic organophosphorus exposure.

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Documento generato il 02/07/20 alle ore 21:40:03