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Titolo:
Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and bladder cancer susceptibility in the Turkish population
Autore:
Toruner, GA; Akyerli, C; Ucar, A; Aki, T; Atsu, N; Ozen, H; Tez, M; Cetinkaya, M; Ozcelik, T;
Indirizzi:
Bilkent Univ, Fac Sci, Dept Mol Biol & Genet, TR-06533 Bilkent, Turkey Bilkent Univ Bilkent Turkey TR-06533 l & Genet, TR-06533 Bilkent, Turkey Univ Hacettepe, Fac Med, Dept Urol, TR-06100 Ankara, Turkey Univ Hacettepe Ankara Turkey TR-06100 Dept Urol, TR-06100 Ankara, Turkey Ataturk Chest Dis Res Hosp, Ankara, Turkey Ataturk Chest Dis Res Hosp Ankara Turkey t Dis Res Hosp, Ankara, Turkey Ankara Numune Hosp, Dept Urol, Ankara, Turkey Ankara Numune Hosp Ankara Turkey Numune Hosp, Dept Urol, Ankara, Turkey
Titolo Testata:
ARCHIVES OF TOXICOLOGY
fascicolo: 8, volume: 75, anno: 2001,
pagine: 459 - 464
SICI:
0340-5761(200110)75:8<459:POGSG(>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NULL GENOTYPE; UROTHELIAL CANCER; RISK; M1; LUNG; P1; T1; EPIDEMIOLOGY; ASSOCIATION; FREQUENCY;
Keywords:
bladder cancer; gene polymorphism; glutathione transferase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ozcelik, T Bilkent Univ, Fac Sci, Dept Mol Biol & Genet, TR-06533 Bilkent,Turkey Bilkent Univ Bilkent Turkey TR-06533 TR-06533 Bilkent, Turkey
Citazione:
G.A. Toruner et al., "Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and bladder cancer susceptibility in the Turkish population", ARCH TOXIC, 75(8), 2001, pp. 459-464

Abstract

We investigated the effect of the GSTM1 and GSTT1 null genotypes, and GSTP1 313 A/G polymorphism on bladder cancer susceptibility in a case control study of 121 bladder cancer patients, and 121 age- and sex-matched controls of the Turkish population. The adjusted odds ratio for age, sex, and smoking status is 1.94 [95% confidence intervals (CI) 1.15-3.26] for the GSTM1 null genotype, and 1.75 (95% CI 1.03-2.99) for the GSTP1 313 A/G or G/G genotypes. GSTT1 was shown not to be associated with bladder cancer. Combinationof the two high-risk genotypes, GSTM1 null and GSTP1 313 A;G or G/G. revealed that the risk increases to 3.91-fol (95% CI 1.88-8.13) compared with the combination of the low-risk genotypes of these loci. In individuals with the combined risk factors of cigarette smoking and the GSTM1 null genotype,the risk of bladder cancer is 2.81 times (95% CI 1.23-6.35) that of persons who both carry the GSTM1-present genotype and do not smoke. Similarly, the risk is 2.38-fold (95% CI 1.12-4.95) for the combined GSTP1 313 A/G and G/G genotypes and smoking. These findings support the role for the GSTM1 null and the GSTP1 313 AG or GG genotypes in the development of bladder cancer. Furthermore, gene-gene (GSTM1-GSTP1) and gene-environment (GSTM1-smoking,GSTP1-smoking) interactions increase this risk substantially.

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Documento generato il 07/07/20 alle ore 14:36:05