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Titolo:
Proliferative activity of CD8(+) T cells as an important clue to analyze Tcell-mediated inflammatory dermatoses
Autore:
Deguchi, M; Ohtani, H; Sato, E; Naito, Y; Nagura, H; Aiba, S; Tagami, H;
Indirizzi:
Tohoku Univ, Sch Med, Dept Dermatol, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ, Grad Sch Med Sci, Dept Pathol, Sendai, Miyagi, Japan Tohoku Univ Sendai Miyagi Japan Sci, Dept Pathol, Sendai, Miyagi, Japan
Titolo Testata:
ARCHIVES OF DERMATOLOGICAL RESEARCH
fascicolo: 9, volume: 293, anno: 2001,
pagine: 442 - 447
SICI:
0340-3696(200109)293:9<442:PAOCTC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN-PRESENTING CAPACITY; CONTACT SENSITIVITY; LANGERHANS CELLS; DENDRITIC CELLS; HOST DISEASE; HYPERSENSITIVITY; LYMPHOCYTES; KERATINOCYTES; CYTOTOXICITY; INDUCTION;
Keywords:
CD8(+) T cell; Ki-67; dermal dendritic cell; lichen planus; graft-versus-host disease; inflammatory skin disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Deguchi, M Tohoku Univ, Sch Med, Dept Dermatol, Aoba Ku, 1-1 Seiryo Machi,Sendai, Miyagi 9808574, Japan Tohoku Univ 1-1 Seiryo Machi Sendai Miyagi Japan 9808574 Japan
Citazione:
M. Deguchi et al., "Proliferative activity of CD8(+) T cells as an important clue to analyze Tcell-mediated inflammatory dermatoses", ARCH DERM R, 293(9), 2001, pp. 442-447

Abstract

To elucidate the pathogenesis of T cell-mediated inflammatory skin diseases, we examined the exact sites where CD8(+) T cells proliferate,, correlating them with the localization of antigen-presenting dendritic cells. We performed CD8/Ki-67 double immunohistochemical staining and, single staining for CD1a,, CD68, and factor XIIIa on sections of paraffin-embedded tissue samples of inflammatory dermatoses, in which T lymphocytes are thought to play a crucial role. The dermatoses: were lichen planus (12 samples), acute graft-versus host disease (GVHD) (12 samples.), chronic GVHD (10 samples), spongiotic dermatitis (8 samples) and psoriasis (7 samples). Labelling for Ki-67. among CD8(+) T cells. was predominantly observed in the subepidermal lymphoid infiltrate, and was scanty in the epidermis. This suggested that proliferation of CD8(+). T cells, occurred preferentially in the dermis. The labelling index for Ki-67 among dermal and epidermal CD8(+) cells was quitedifferent among the different diseases studied (P < 0.05). They were rich in the subepidermal portion of the dermis of spongiotic dermatitis, acute GVHD and chronic GVHD, but rare in the dermis of psoriasis and lichen planus. A moderate infiltrate was also observed in lesional epidermis, of spongiotic dermatitis, acute GVHD and chronic GVHD:, whereas they was almost none in the epidermis of psoriasis and lichen planus. CD1a(+) dermal dendritic cells were densely distributed within the lymphoid infiltrate in the affected dermis of spongiotic dermatitis, psoriasis and lichen planus, whereas they were minimal in GVHD. These dermal dendritic cells are candidates as stimulators on T cells in the dermis. In conclusion, the proliferative status of T cells could be an important clue in the elucidation of the pathophysiology of T cell-mediated inflammatory dermatoses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:27:30