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Titolo:
Autologous transplantation in acute myeloid leukemia: peripheral blood stem cell harvest after mobilization in steady state by granulocyte colony-stimulating factor alone
Autore:
Voog, E; Le, QL; Philip, I; Benetaib, B; Michallet, M; Fiere, D; Thomas, X;
Indirizzi:
Hop Edouard Herriot, Serv Hematol, F-69437 Lyon 03, France Hop Edouard Herriot Lyon France 03 Serv Hematol, F-69437 Lyon 03, France Hop Edouard Herriot, Serv Malad Sang, F-69437 Lyon, France Hop Edouard Herriot Lyon France F-69437 Malad Sang, F-69437 Lyon, France Ctr Leon Berard, Lab Cryobiol, F-69373 Lyon, France Ctr Leon Berard LyonFrance F-69373 , Lab Cryobiol, F-69373 Lyon, France
Titolo Testata:
ANNALS OF HEMATOLOGY
fascicolo: 10, volume: 80, anno: 2001,
pagine: 584 - 591
SICI:
0939-5555(200110)80:10<584:ATIAML>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; HIGH-DOSE CHEMOTHERAPY; ACUTE MYELOGENOUS LEUKEMIA; RAPID HEMATOPOIETIC RECOVERY; ACUTE PROMYELOCYTIC LEUKEMIA; NON-HODGKINS-LYMPHOMA; PROGENITOR CELLS; G-CSF; SEQUENTIAL CHEMOTHERAPY; INTENSIVE CHEMOTHERAPY;
Keywords:
acute myeloid leukemia; autologous transplant; granulocyte colony-stimulating factor (G-CSF); peripheral blood stem cell; steady state;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Thomas, X Hop Edouard Herriot, Serv Hematol, F-69437 Lyon 03, France Hop Edouard Herriot Lyon France 03 ol, F-69437 Lyon 03, France
Citazione:
E. Voog et al., "Autologous transplantation in acute myeloid leukemia: peripheral blood stem cell harvest after mobilization in steady state by granulocyte colony-stimulating factor alone", ANN HEMATOL, 80(10), 2001, pp. 584-591

Abstract

In order to determine whether granulocyte colony-stimulating factor (G-CSF) alone initiated during steady state was able to mobilize peripheral bloodstem cells (PBSC) in acute myeloid leukemia (AML) and to assess predictivefactors for engraftment after autologous PBSC transplantation, we studied 49 successive adult AML patients for whom autologous transplantation was planned between July 1994 and November 1998. G-CSF was used as priming agent and was initiated at least 4 weeks after the last day of chemotherapy, while neutrophil count was >0.5x10(9)/1 and platelet count was >30x10(9)/1. A median of three aphereses was performed resulting in a median collection of 14.8x10(8) nucleated cells/kg containing 7.7x10(8) mononuclear cells/kg, 47.1x10(4) CFU-GM/kg, and 3.8x10(6) CD34(+) cells/kg. A significant correlation was observed between nucleated cell, mononuclear cell, and CFU-GM yields, while no correlation was found with CD34+ cell yield. Recruitment was notsignificantly different in patients with CD34+ leukemic cells at the time of initial diagnosis when compared to that of those presenting, with CD34(-) blastic cells. Thirty-three patients actually underwent transplantation. Reasons for not autografting were inadequate stem cell harvest (ten patients), early relapse (two patients), prolonged neutropenia (one patient), organ failure (two patients), or patient refusal (one patient). Median time to achieve a neutrophil count greater than 0.5x10(9)/1 and platelet count >50x10(9)/1 untransfused was 13 and 36 days, respectively. A predictive factor for a shorter period neutropenia and a shorter thrombopenia was a higher count of harvested nucleated cells (p<0.01 and p=0.02, respectively). A higher count of harvested cells was also a predictive factor for less red cell and platelet transfusions (p=0.03 and p=0.02, respectively). The number of CD34(+) harvested PBSC was not predictive for engraftment. We conclude that PBSC mobilization with G-CSF alone initiated in steady state is a feasible,safe, and suitable procedure for harvesting cells in sight of autologous transplantation in adult acute myeloid leukemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:57:59