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Titolo:
Polyethylene glycol/surfactant mixtures improve lung function after HCl and endotoxin lung injuries
Autore:
Lu, KW; Taeusch, HW; Robertson, B; Goerke, J; Clements, JA;
Indirizzi:
Univ Calif San Francisco, Dept Pediat & Physiol, San Francisco, CA USA Univ Calif San Francisco San Francisco CA USA iol, San Francisco, CA USA Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USAUniv Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Karolinska Inst, Dept Women & Child Hlth, Stockholm, Sweden Karolinska Inst Stockholm Sweden Women & Child Hlth, Stockholm, Sweden
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 8, volume: 164, anno: 2001,
pagine: 1531 - 1536
SICI:
1073-449X(20011015)164:8<1531:PGMILF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; WATER-SOLUBLE POLYMERS; ACID ASPIRATION; INTRATRACHEAL ENDOTOXIN; SURFACE-ACTIVITY; ANIMAL-MODEL; RATS; INACTIVATION; MECONIUM; PATHOGENESIS;
Keywords:
polymer; surfactant; lung injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Lu, KW San Francisco Gen Hosp, Dept Pediat, MS 6E,1001 Potrero Ave, San Francisco, CA 94110 USA San Francisco Gen Hosp MS 6E,1001 Potrero Ave San Francisco CA USA 94110
Citazione:
K.W. Lu et al., "Polyethylene glycol/surfactant mixtures improve lung function after HCl and endotoxin lung injuries", AM J R CRIT, 164(8), 2001, pp. 1531-1536

Abstract

Addition of nonionic polymers such as polyethylene glycol (PEG) and dextran ameliorates inactivation of Survanta by a variety of substances in vitro,Addition of polymers to Survanta also improves pulmonary function when used to treat rats with lung injury caused by instillation of human meconium. To find whether this approach is effective in lung injuries that more closely resemble adult respiratory distress syndrome (ARDS), we have compared the use of Survanta with Survanta + PEG in two additional models of lung injury caused by either lipopolysaccharide (LPS) or HCI in adult rats. Significant improvement of serial measures for arterial oxygenation and of postmortem pressure-volume measurements were found after treatment with Survanta + PEG compared with Survanta alone. PEG added to Survanta increased resistance to inactivation caused by tracheal fluid taken from animals injured with HCI. Other work suggests that PEG promotes surfactant aggregation, separates surfactant from surfactant inhibitors, and enhances access of surfactant to the gas-liquid interface. The addition of polymers to surfactants may also be useful in the treatment of lung injury where inactivation of surfactant has already occurred.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:59:42