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Titolo:
Inflammatory response and body composition in chronic obstructive pulmonary disease
Autore:
Eid, AA; Ionescu, AA; Nixon, LS; Lewis-Jenkins, V; Matthews, SB; Griffiths, TL; Shale, DJ;
Indirizzi:
Univ Wales Coll Med, Sect Resp Med, Penarth CF64 2XX, S Glam, Wales Univ Wales Coll Med Penarth S Glam Wales CF64 2XX CF64 2XX, S Glam, Wales Llandough Hosp, Cardiff & Vale NHS Trust, Dept Nutr & Dietet, Penarth GP6 1XX, S Glam, Wales Llandough Hosp Penarth S Glam Wales GP6 1XX enarth GP6 1XX, S Glam, Wales Llandough Hosp, Cardiff & Vale NHS Trust, Dept Med Biochem, Penarth GP6 1XX, S Glam, Wales Llandough Hosp Penarth S Glam Wales GP6 1XX enarth GP6 1XX, S Glam, Wales
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 8, volume: 164, anno: 2001,
pagine: 1414 - 1418
SICI:
1073-449X(20011015)164:8<1414:IRABCI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; RESTING ENERGY-EXPENDITURE; CHRONIC HEART-FAILURE; FACTOR-ALPHA; NUTRITIONAL ASSESSMENT; MALNOURISHED PATIENTS; CYSTIC-FIBROSIS; EMPHYSEMA; WEIGHT; COPD;
Keywords:
body composition; chronic obstructive pulmonary disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Shale, DJ Univ Wales Coll Med, Llandough Hosp & Community NHS Trust, Sect Resp Med, Penarth CF64 2XX, S Glam, Wales Univ Wales Coll Med Penarth S Glam Wales CF64 2XX S Glam, Wales
Citazione:
A.A. Eid et al., "Inflammatory response and body composition in chronic obstructive pulmonary disease", AM J R CRIT, 164(8), 2001, pp. 1414-1418

Abstract

Weight loss in chronic obstructive airways disease (COPD) is associated with an increased energy cost of breathing. To determine an association between body composition and the inflammatory response we studied 80 clinically stable patients. Body composition was determined anthropometrically and skeletal muscle mass was determined as the creatinine-height index (CHI). Forty patients had their nitrogen balance determined. Circulating concentrations of interieukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and their soluble receptors were determined for 68 patients. Body mass index (BMI)was normal (> 20 kg/m(2)) in 55 patients, of whom 17 (31%) had a low CHI (< 80% predicted). A reduced CHI was associated with increased circulating levels of IL-6 (p = 0.001), TNF-alpha (p = 0.032) and their soluble receptors IL-6sr (p = 0.002), TNF-alpha sr1 (p = 0.03), and TNF-alpha sr2 (p = 0.001). Patients with a normal. BMI and low CHI had inflammatory mediator levels similar to patients with a low BMI and CHI; both were significantly greater than in those with a normal BMI and CHI. Nitrogen balance was similar between normal and low CHI groups, although nitrogen excretion was significantly increased in the low CHI group. Skeletal muscle loss in CORD is probably multifactorial in origin, but our data suggest a link with systemic inflammation, even when weight loss is inapparent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 20:29:52