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Titolo:
Relationship between bronchial responsiveness and clinical evolution in infants who wheeze - A four-year prospective study
Autore:
Delacourt, C; Benoist, MR; Waernessyckle, S; Rufin, P; Brouard, JJ; De Blic, J; Scheinmann, P;
Indirizzi:
Hop Necker Enfants Malad, Serv Pneumol & Allergol Pediat, Lab Explorat Fonctionnelles Resp, F-75015 Paris, France Hop Necker Enfants Malad Paris France F-75015 esp, F-75015 Paris, France
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 8, volume: 164, anno: 2001,
pagine: 1382 - 1386
SICI:
1073-449X(20011015)164:8<1382:RBBRAC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCUTANEOUS OXYGEN-TENSION; INDUCED AIRWAY-OBSTRUCTION; LUNG-FUNCTION TESTS; YOUNG-CHILDREN; METHACHOLINE CHALLENGE; ILLNESS; LIFE; REPEATABILITY; REACTIVITY; HISTAMINE;
Keywords:
asthma; lung function; methacholine; airway remodeling; bronchiolitis; infantile asthma; bronchial hyperreactivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Benoist, MR Hop Necker Enfants Malad, Serv Pneumol & Allergol Pediat, Lab Explorat Fonctionnelles Resp, 149 Rue Sevres, F-75015 Paris, France Hop Necker Enfants Malad 149 Rue Sevres Paris France F-75015
Citazione:
C. Delacourt et al., "Relationship between bronchial responsiveness and clinical evolution in infants who wheeze - A four-year prospective study", AM J R CRIT, 164(8), 2001, pp. 1382-1386

Abstract

Recurrent illness involving wheezing during the first years of life is transient in most children. The role of bronchial hyperresponsiveness as a factor influencing the persistence of wheezing from infancy to school age remains unknown. In a prospective study we investigated whether infants who wheezed and subsequently developed persistent asthma differed from infants whowheezed and later became asymptomatic either in the initial degree of bronchial hyperresponsiveness or in the persistence of bronchial hyperresponsiveness with age. One hundred and twenty-nine infants with three or more wheezing episodes before 2yr of age were followed during 4yr with a clinical evaluation and a methacholine challenge performed every 6 mo until the child was 4 yr old and once per year thereafter. The clinical score significantlyimproved with time in most children. The proportion of children with persistent wheezing after 2 and 4 yr of follow-up was only 31% and 20%, respectively. Persistent wheezers had significantly lower VmaxFRC values at initialevaluation and higher SRaw values at the end of follow-up than infants whobecame asymptomatic. We used transcutaneous oxygen tension (PtcO(2)) to measure the response to methacholine. No significant difference in PD15 PtcO(2) between groups with subsequently different clinical progression was observed at initial evaluation. Bronchial hyperresponsiveness persisted 4 yr later in all children but children with persistent wheezing showed significantly lower PD15 PtcO(2) values than children who became asymptomatic, as early as 30 mo of age. However, an acceptable early PD15 PtcO(2) cut-off pointpredictive for subsequent clinical progression. could not be identified. The level of bronchial hyperresponsiveness in infants who wheezed was riot predictive of the persistence of asthma 4 yr later.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 11:52:25