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Titolo:
Determinants of low birth weight among HIV-infected pregnant women in Tanzania
Autore:
Dreyfuss, ML; Msamanga, GI; Spiegelman, D; Hunter, DJ; Urassa, EJN; Hertzmark, E; Fawzi, WW;
Indirizzi:
Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA Harvard UnivBoston MA USA 02115 bl Hlth, Dept Nutr, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hlth, Dept Biostat, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA Muhimbili Univ, Coll Hlth Sci, Dept Community Hlth, Dar Es Salaam, Tanzania Muhimbili Univ Dar Es Salaam Tanzania ity Hlth, Dar Es Salaam, Tanzania Muhimbili Univ, Coll Hlth Sci, Dept Obstet & Gynecol, Dar Es Salaam, Tanzania Muhimbili Univ Dar Es Salaam Tanzania Gynecol, Dar Es Salaam, Tanzania
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 6, volume: 74, anno: 2001,
pagine: 814 - 826
SICI:
0002-9165(200112)74:6<814:DOLBWA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; PLASMODIUM-FALCIPARUM; INTESTINAL PARASITES; SEROPOSITIVE WOMEN; RANDOMIZED TRIAL; MALARIA CONTROL; INFANTS BORN; FETAL GROWTH; CHLOROQUINE; TYPE-1;
Keywords:
HIV infection; pregnancy; low birth weight; small for gestational age; Tanzania; vertical transmission; malaria; parasitic infections;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Dreyfuss, ML Johns Hopkins Bloomberg Sch Publ Hlth, Dept Populat & Family Hlth Sci, 615N Wolfe St,Room W4033, Baltimore, MD 21205 USA Johns Hopkins Bloomberg Sch Publ Hlth 615 N Wolfe St,Room W4033 Baltimore MD USA 21205
Citazione:
M.L. Dreyfuss et al., "Determinants of low birth weight among HIV-infected pregnant women in Tanzania", AM J CLIN N, 74(6), 2001, pp. 814-826

Abstract

Background: Low birth weight (LBW) increases the risk of infant death, butlittle is known about its causes among HIV-infected populations in sub-Saharan Africa. Objective: We assessed sociodemographic, nutritional, immunologic, parasitic, and infant risk factors for birth weight, LBW, and V small-for-gestational-age (SGA) status in a cohort of 822 HIV-positive women enrolled in a clinical trial of vitamin supplementation and pregnancy outcomes in Dar es Salaam, Tanzania. Design: Women were enrolled at prenatal care clinics during their second trimester, at which time blood, stool, urine, and genital specimens were collected, and anthropometric measurements and sociodemographic data were recorded. Birth weight was measured at hospital delivery. Results: The mean (+/- SD) birth weight was 3015 +/- 508 g, 11.1 % of newborns weighed < 2500 g (LBW), and 11.5% were SGA. In multivariate analyses, maternal weight at enrollment and a low CD8 cell count were inversely associated with LBW. Advanced stage HIV disease, previous history of preterm birth, Plasmodium falciparum malaria, and any helmintic infection were associated with hi-her risk of LBW. The intestinal parasites Entamoeba histolyticaand Strongyloides stercoralis were predictors of LBW despite their low prevalence in the cohort. In a multivariate-adjusted linear regression model, BMI, midupper arm circumference, a CD4 cell count < 200 X 10(6) cells/L (200 cells/mm(3)), primiparity, maternal literacy, and infant HIV infection atbirth were significantly associated with birth weight in addition to risk factors included in the LBW model. Determinants of SGA included maternal weight, low serum vitamin E concentration, candidiasis, malaria, and infant HIV infection at birth. Conclusion: Prevention of HIV disease progression and vertical transmission, improved nutritional status, and better management of malaria and intestinal parasitic infections are likely to reduce the incidence of LBW in Tanzania.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:50:00