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Titolo:
Evidence that the Lore-1 region specifies ethanol-induced activation in addition to sedative/hypnotic sensitivity to ethanol
Autore:
Owens, JC; Bennett, B; Johnson, TE;
Indirizzi:
Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 nst Behav Genet, Boulder, CO 80309 USA Univ Colorado, Dept Psychol, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 o, Dept Psychol, Boulder, CO 80309 USA
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 11, volume: 25, anno: 2001,
pagine: 1551 - 1557
SICI:
0145-6008(200111)25:11<1551:ETTLRS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-SLEEP MICE; RECOMBINANT INBRED STRAINS; QUANTITATIVE TRAIT LOCI; BRED LONG-SLEEP; LOCOMOTOR-ACTIVITY; INDUCED ANESTHESIA; GENETIC-ANALYSIS; ALCOHOL; TOLERANCE; NEUROTENSIN;
Keywords:
alcoholism; genetics; selected lines; ILS; ISS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, TE Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 net, Boulder, CO 80309 USA
Citazione:
J.C. Owens et al., "Evidence that the Lore-1 region specifies ethanol-induced activation in addition to sedative/hypnotic sensitivity to ethanol", ALC CLIN EX, 25(11), 2001, pp. 1551-1557

Abstract

Background: Low-dose ethanol-induced activation (LDA) and initial sensitivity to alcohol are both predictors of alcohol abuse in human populations. Our hypothesis is that one or more genes specifying hypnotic sensitivity also specify LDA. We tested this hypothesis by using congenic mice derived from the inbred long-sleep (ILS) and inbred short-sleep (ISS) strains, which carry an ILS region introgressed onto an ISS background. Methods: LDA was assessed by assigning mice randomly to receive one of five doses of ethanol ranging from 1.2 to 2.4 g/kg. On day 1, animals were injected with saline and placed in a brightly lit activity monitor for 30 min,after which they were returned to their home cages. On day 2, mice were injected with ethanol (20% w/v), their activity was monitored for a 30-min period, and LDA was determined by subtracting day 1 activity. The blood ethanol concentration of each animal was then assessed at 30 min by retro-orbital collection of 25 mul of blood. Results: Ethanol had a significant effect on the activity of ISS mice, butILS mice showed no activation at any dose, similar to the activities of the outbred lines. All three congenic strains were activated at several doses. Lore-2 and Lore-5 were not ILS-like (less active than ISS) at any dose. In contrast, ISS.ILS-Lore-1 congenics (carrying an ILS-derived Lore-1 alleleon the ISS background) were significantly less activated than the ISS controls at 1.8 and 2.4 g/kg of ethanol. Conclusions: The Lore-2 and Lore-5 congenic regions do not affect LDA. In contrast, the Lore-1 congenic region carries one or more genes specifying both initial hypnotic sensitivity to ethanol and LDA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:03:42