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Titolo:
Is systematic biopsy of the transition zone a necessary supplement to sextant biopsy of the prostate?
Autore:
Manseck, A; Frohner, M; Guhr, K; Hakenberg, OW; Wirth, MP;
Indirizzi:
Tech Univ Dresden, Univ Klinikum Carl Gustav Carus, Klin & Poliklin Urol, D-01307 Dresden, Germany Tech Univ Dresden Dresden Germany D-01307 Urol, D-01307 Dresden, Germany
Titolo Testata:
AKTUELLE UROLOGIE
fascicolo: 6, volume: 32, anno: 2001,
pagine: 368 - 371
SICI:
0001-7868(200110)32:6<368:ISBOTT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
GER
Soggetto:
CANCER; SECTOR;
Keywords:
transition zone biopsy; sextant biopsy; prostate cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Manseck, A Tech Univ Dresden, Univ Klinikum Carl Gustav Carus, Klin & Poliklin Urol, Fetscherstasse 74, D-01307 Dresden, Germany Tech Univ Dresden Fetscherstasse 74 Dresden Germany D-01307 ny
Citazione:
A. Manseck et al., "Is systematic biopsy of the transition zone a necessary supplement to sextant biopsy of the prostate?", AKT UROL, 32(6), 2001, pp. 368-371

Abstract

Introduction: The aim of this study was to evaluate the diagnostic value of performing 4 additional transition zone biopsies in patients undergoing routine sextant biopsy of the prostate. Patients and methods: A total of 324 patients with a serum prostate specific antigen (PSA) elevation > 4 ng/ml (n = 287) and/or a suspicious digital rectal examination (n = 127) were evaluated prospectively. Of the 324,170 patients had already undergone one or more previous sets of negative prostatic biopsies. In all patients, 4 transition zone biopsies were taken in addition to a routine, ultrasound-guided sextant biopsy. Results: Prostate cancer was found in 110 of the 324 patients. Positive biopsies were located in the transition zones of only 10 of these 110 patients, in the peripheral zones in 32 and 68 patients showed cancer in both peripheral and transition zone biopsy cores. Prostate cancers seen exclusively in the transition zones were predominantly non-palpable pT1c tumours (7/10)with PSA values between 4 and 10 ng/ml. Compared to patients without previous biopsies, in those patients with previously negative prostate biopsies the tumour detection rate of this 10-core-biopsy technique was similar bothfor overall tumour detection (32,9 % vs 35,1 %) as well as for the detection of prostate cancers found exclusively in the transition zones (2,4 % vs 3,9 %). Conclusions: Taking four additional transition zone biospies with a routine sextant prostate biopsy only marginally increases the overall tumour detection rate. It does, however, lead to the detection of a small number of prostate cancers confined to the transition zone, which present with PSA-elevation and negative digital rectal findings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 19:40:38