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Titolo:
Generalization of the normalized dose-response gradient to non-uniform dose delivery
Autore:
Lind, BK; Nilsson, J; Lof, J; Brahme, A;
Indirizzi:
Stockholm Univ, SE-17176 Stockholm, Sweden Stockholm Univ Stockholm Sweden SE-17176 niv, SE-17176 Stockholm, Sweden Karolinska Hosp, Karolinska Inst, Dept Med Radiat Phys, S-10401 Stockholm,Sweden Karolinska Hosp Stockholm Sweden S-10401 Phys, S-10401 Stockholm,Sweden
Titolo Testata:
ACTA ONCOLOGICA
fascicolo: 6, volume: 40, anno: 2001,
pagine: 718 - 724
SICI:
0284-186X(2001)40:6<718:GOTNDG>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-THERAPY; TUMOR; OPTIMIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Lind, BK Karolinska Inst, Dept Med Radiat Phys Oncol Pathol, POB 260, SE-17176 Stockholm, Sweden Karolinska Inst POB 260 Stockholm Sweden SE-17176 ckholm, Sweden
Citazione:
B.K. Lind et al., "Generalization of the normalized dose-response gradient to non-uniform dose delivery", ACTA ONCOL, 40(6), 2001, pp. 718-724

Abstract

A generalization of the standard dose-response gradient to arbitrarily heterogeneous dose distributions has been developed. The generalized dose-response gradient is the scalar product of the vector representing the dose distribution and the gradient of the dose-response relation with respect to that dose vector. It is shown that, for a tumor, the individual gamma -valuesfor each portion of the tumor divided by the corresponding local tumor control probability should be added to get the total value for the heterogeneously irradiated tumor. This corresponds to summing up the contributions of all tumor volumes so that the total Value of the gradient is related to thelogarithm of the total tumor clonogen number. General expressions are alsoderived for the change in the dose-response relation as a function of a change in the delivered dose distribution.

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Documento generato il 02/12/20 alle ore 14:40:53