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Titolo:
The inherited basis of human radiosensitivity
Autore:
Gatti, RA;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Pathol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
ACTA ONCOLOGICA
fascicolo: 6, volume: 40, anno: 2001,
pagine: 702 - 711
SICI:
0284-186X(2001)40:6<702:TIBOHR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIJMEGEN BREAKAGE SYNDROME; ATAXIA-TELANGIECTASIA GENE; DNA-DAMAGE RESPONSE; BREAST-CANCER PATIENTS; COMMON VARIABLE IMMUNODEFICIENCY; CHROMOSOMAL INSTABILITY DISORDER; ATM-DEPENDENT PHOSPHORYLATION; EARLY EMBRYONIC LETHALITY; DOUBLE-STRAND BREAKS; GROUP-C PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Gatti, RA Univ Calif Los Angeles, Sch Med, Dept Pathol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 s, CA 90095 USA
Citazione:
R.A. Gatti, "The inherited basis of human radiosensitivity", ACTA ONCOL, 40(6), 2001, pp. 702-711

Abstract

Certain individuals cannot tolerate 'conventional' doses of radiation therapy. This is known to be true of patients with ataxia-telangiectasia and ligase IV deficiency. Although in vitro testing may not correlate completely with clinical radiosensitivity, fibroblasts and lymphoblasts from patients,vith both of these disorders have been clearly shown to be radiosensitive. Using a colony survival assay (CSA) to test lymphoblastoid cells after irradiation with 1 Gy, a variety of other genetic disorders have been identified as strong candidates for clinical radiosensitivity. such as Nijmegen breakage syndrome, Mrel 1 deficiency, and Fanconi's anemia. These data are presented and considered as a starting-point for the inherited basis of human radiosensitivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 17:49:12