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Titolo:
Distribution of cerebral cortical lesions in Pick's disease with Pick bodies: a clinicopathological study of six autopsy cases showing unusual clinical presentations
Autore:
Tsuchiya, K; Ikeda, M; Hasegawa, K; Fukui, T; Kuroiwa, T; Haga, C; Oyanagi, S; Nakano, I; Matsushita, M; Yagishita, S; Ikeda, K;
Indirizzi:
Tokyo Metropolitan Matsuzawa Hosp, Dept Lab Med & Pathol, Setagaya Ku, Tokyo 1560057, Japan Tokyo Metropolitan Matsuzawa Hosp Tokyo Japan 1560057 kyo 1560057, Japan Tokyo Inst Psychiat, Dept Neuropathol, Tokyo, Japan Tokyo Inst Psychiat Tokyo Japan sychiat, Dept Neuropathol, Tokyo, Japan Ehime Univ, Dept Neuropsychiat, Matsuyama, Ehime 790, Japan Ehime Univ Matsuyama Ehime Japan 790 sychiat, Matsuyama, Ehime 790, Japan Natl Sagamihara Hosp, Dept Neurol, Kanagawa, Japan Natl Sagamihara Hosp Kanagawa Japan Hosp, Dept Neurol, Kanagawa, Japan Showa Univ, Dept Neurol, Tokyo, Japan Showa Univ Tokyo JapanShowa Univ, Dept Neurol, Tokyo, Japan Tokyo Med & Dent Univ, Dept Neuropathol, Tokyo, Japan Tokyo Med & Dent Univ Tokyo Japan Univ, Dept Neuropathol, Tokyo, Japan Nagaokaryoikuen, Dept Psychiat, Niigata, Japan Nagaokaryoikuen Niigata Japan karyoikuen, Dept Psychiat, Niigata, Japan Jichi Med Sch, Dept Neurol, Minami Kawachi, Tochigi 32904, Japan Jichi MedSch Minami Kawachi Tochigi Japan 32904 hi, Tochigi 32904, Japan Kanagawa Rehabil Ctr, Dept Pathol, Kanagawa, Japan Kanagawa Rehabil Ctr Kanagawa Japan l Ctr, Dept Pathol, Kanagawa, Japan
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 6, volume: 102, anno: 2001,
pagine: 553 - 571
SICI:
0001-6322(200112)102:6<553:DOCCLI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; BASAL GANGLIA LESIONS; CORTICOBASAL DEGENERATION; FRONTOTEMPORAL DEMENTIA; LOBAR ATROPHY; TAU; APHASIA; ALZHEIMERS; LANGUAGE; APHEMIA;
Keywords:
speech apraxia; cerebral cortical lesion; extrapyramidal sign; depression; Pick bodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuchiya, K Tokyo Metropolitan Matsuzawa Hosp, Dept Lab Med & Pathol, Setagaya Ku, 2-1-1 Kamikitazawa, Tokyo 1560057, Japan Tokyo Metropolitan Matsuzawa Hosp 2-1-1 Kamikitazawa Tokyo Japan 1560057
Citazione:
K. Tsuchiya et al., "Distribution of cerebral cortical lesions in Pick's disease with Pick bodies: a clinicopathological study of six autopsy cases showing unusual clinical presentations", ACT NEUROP, 102(6), 2001, pp. 553-571

Abstract

We investigated six Japanese autopsy cases of Pick's disease with Pick bodies (PDPB) both clinically and pathologically, and examined the distribution of their cerebral cortical lesions using hemisphere and/or bisphere specimens. The lesions were classified into three categories (slight, moderate, and severe). Two patients with a clinical diagnosis of primary progressive apraxia and of slowly progressive aphasia had speech apraxia as their initial signs, and the other two patients were suspected as having Alzheimer's disease, with the clinical diagnosis of the remainder two patients being presenile dementia and depression, respectively. Extrapyramidal signs, believed to be rare in PDPB, were present in four patients.. Severe lesions were multicentrically present in the cerebral cortices of all six cases. In two patients with speech apraxia, severe lesions were seen in the primary motor area, which generally has not been regarded as an "atrophic center" in Pick's disease. Furthermore, in a patient with depression, severe lesions were more widespread in the convexity than in the orbital region of the frontal lobe. The parietal lobes, including the postcentral gyrus usually believed to be spared in Pick's disease, were severely involved in three patients. We postulate that the clinical features of PDPB have a much wider spectrum than previously believed. In addition, we believe that the distribution of the cerebral cortical lesions in PDPB is more widespread than previously assumed, and that clinical manifestations of PDPB depend to some extent on thetopographic distribution of the cerebral cortical lesions.

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Documento generato il 02/07/20 alle ore 21:11:37