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Titolo:
Birth of MHC-defined rhesus monkeys produced by assisted reproductive technology
Autore:
Schramm, RD; Paprocki, AM; Watkins, DI;
Indirizzi:
Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Madison, WI 53715 USA Univ Wisconsin Madison WI USA 53715 rimate Res Ctr, Madison, WI 53715 USA Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53715 USA Univ Wisconsin Madison WI USA 53715 thol & Lab Med, Madison, WI 53715 USA
Titolo Testata:
VACCINE
fascicolo: 3-4, volume: 20, anno: 2001,
pagine: 603 - 607
SICI:
0264-410X(20011112)20:3-4<603:BOMRMP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; FOLLICLE-STIMULATING-HORMONE; POLYMERASE CHAIN-REACTION; CYTOTOXIC T-LYMPHOCYTES; HUMAN EMBRYOS; INVITRO FERTILIZATION; IN-VITRO; PREIMPLANTATION DEVELOPMENT; NONHUMAN-PRIMATES; MONOZYGOTIC TWINS;
Keywords:
SIV vaccine; MHC-defined monkeys; assisted reproductive technology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Schramm, RD Univ Wisconsin, Wisconsin Reg Primate Res Ctr, 1223 Capitol Court, Madison, WI 53715 USA Univ Wisconsin 1223 Capitol Court Madison WI USA53715 715 USA
Citazione:
R.D. Schramm et al., "Birth of MHC-defined rhesus monkeys produced by assisted reproductive technology", VACCINE, 20(3-4), 2001, pp. 603-607

Abstract

One of the best animal approaches for testing HIV vaccines is the challenge of vaccinated rhesus macaques with SHIV or SIV. Production of rhesus macaques in which all of the MHC class I and II alleles are known represents anopportunity to characterize the entire immune response to SIV and should be an invaluable resource for understanding pathogenesis and vaccine-inducedimmune responses. Unfortunately, there are few MHC-defined rhesus macaquesavailable for vaccine research. Selective breeding supports the productionof limited numbers of macaques that express particular MHC class I alleles. If both parents express the allele of interest, only three quarters of the offspring will express the same allele, However, assisted reproductive technologies, such as in vitro fertilization (IVF) and embryo transfer, can be used for production of MHC-defined macaques, expressing multiple MHC class I and II molecules for which SIV peptides. tetramers and ELISPOT assays exist. Here, we report the birth of MHC-defined rhesus monkeys produced by assisted reproductive technology. Continued improvements in assisted reproductive technologies in rhesus monkeys will enable us to develop a unique prototypic animal production program for the creation of MHC-defined and genetically-identical monkeys for vaccine research. (C) 2001 Elsevier Science Ltd. All rights reserved.

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Documento generato il 25/01/20 alle ore 03:25:30