Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Randomized trial of the quantitative and functional antibody responses to a 7-valent pneumococcal conjugate vaccine and/or 23-valent polysaccharide vaccine among HIV-infected adults
Autore:
Feikin, DR; Elie, CM; Goetz, MB; Lennox, JL; Carlone, GM; Romero-Steiner, S; Holder, PF; OBrien, WA; Whitney, CG; Butler, JC; Breiman, RF;
Indirizzi:
CDCP, Natl Ctr Infect Dis, Div Bacterial & Mycot Dis, Resp Dis Branch, Atlanta, GA 30332 USA CDCP Atlanta GA USA 30332 cot Dis, Resp Dis Branch, Atlanta, GA 30332 USA Univ Calif Los Angeles, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA s Angeles, Los Angeles, CA USA VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA VA Greater LosAngeles Healthcare Syst Los Angeles CA USA ngeles, CA USA Emory Univ, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322Emory Univ, Atlanta, GA 30322 USA Grady Infect Dis Program, Atlanta, GA USA Grady Infect Dis Program Atlanta GA USA ect Dis Program, Atlanta, GA USA Univ Texas, Med Branch, Galveston, TX 77550 USA Univ Texas Galveston TX USA 77550 as, Med Branch, Galveston, TX 77550 USA
Titolo Testata:
VACCINE
fascicolo: 3-4, volume: 20, anno: 2001,
pagine: 545 - 553
SICI:
0264-410X(20011112)20:3-4<545:RTOTQA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; STREPTOCOCCUS-PNEUMONIAE; GLYCOPROTEIN CONJUGATE; DISEASE; CHILDREN; ASSAY;
Keywords:
pneumococcal disease; conjugate vaccines; HIV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Feikin, DR CDCP, Natl Ctr Infect Dis, Div Bacterial & Mycot Dis, Resp Dis Branch, 1600 Clifton Rd,MS-C23, Atlanta, GA 30332 USA CDCP 1600 Clifton Rd,MS-C23 Atlanta GA USA 30332 , GA 30332 USA
Citazione:
D.R. Feikin et al., "Randomized trial of the quantitative and functional antibody responses to a 7-valent pneumococcal conjugate vaccine and/or 23-valent polysaccharide vaccine among HIV-infected adults", VACCINE, 20(3-4), 2001, pp. 545-553

Abstract

In a double-blinded, randomized trial, human immunodeficiency virus (HIV)-infected adults with greater than or equal to 200 CD4 cells/mul received placebo (PL), 7-valent conjugate. or 23-valent pneumococcal polysaccharide (PS) vaccine in one of the following two-dose combinations given 8 weeks apart: conjugate-conjugate, conjugate-polysaccharide. placebo-polysaccharide, placebo-placebo. A total of 67 persons completed the study. Neither significant increases in HIV viral load nor severe adverse reactions occurred in any group. After controlling for confounders. when compared with persons receiving placebo-polysaccharide, persons receiving conjugate-conjugate and conjugate-polysaccharide had higher antibody concentrations (serotypes 4. 6B, 9V and serotype 23F respectively) and opsonophagocytic titers (functional antibody assay, serotypes 9V, 23F and serotypes 4, 6B, 9V. respectively) after the second dose (P < 0.05). The second dose with either conjugate or polysaccharide following the first conjugate dose, however, produced no further increase in immune responses. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 05:38:01