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Titolo:
Rectal immunization with antigen-containing microspheres induces stronger Th2 responses than oral immunization: a new method for vaccination
Autore:
Nakase, H; Okazaki, K; Tabata, Y; Uchida, K; Uose, S; Ohana, M; Nishi, T; Watanabe, T; Matsuura, M; Hisatsune, H; Matsumura, K; Itoh, T; Kawanami, C; Chiba, T;
Indirizzi:
Kyoto Univ, Grad Sch, Div Gastroenterol & Endoscop Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 oscop Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Inst Frontier Med Sci, Kyoto 6068507, Japan Kyoto Univ KyotoJapan 6068507 st Frontier Med Sci, Kyoto 6068507, Japan
Titolo Testata:
VACCINE
fascicolo: 3-4, volume: 20, anno: 2001,
pagine: 377 - 384
SICI:
0264-410X(20011112)20:3-4<377:RIWAMI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUCOSAL IMMUNE-SYSTEM; ANTIBODY-PRODUCING CELLS; CHOLERA-TOXIN; LABILE ENTEROTOXIN; PERIPHERAL-BLOOD; IMMUNOGLOBULIN-G; IGE ANTIBODY; INDUCTION; MICE; ADJUVANT;
Keywords:
rectal immunizations; microspheres; Th2-type response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Okazaki, K Kyoto Univ, Grad Sch, Div Gastroenterol & Endoscop Med, Sakyo Ku, 54 Shogoinkawara Cho, Kyoto 6068507, Japan Kyoto Univ 54 Shogoinkawara Cho Kyoto Japan 6068507 507, Japan
Citazione:
H. Nakase et al., "Rectal immunization with antigen-containing microspheres induces stronger Th2 responses than oral immunization: a new method for vaccination", VACCINE, 20(3-4), 2001, pp. 377-384

Abstract

The rectum as an effective site for induction of systemic and local immunity has received little attention. Rectal immunization with microspheres-containing ovalbumin (MS-OVA) was tested for its ability to elicit systemic and mucosal immune responses. Rectal immunization with MS-OVA enhanced both Th2 dominant OVA-specific IgG levels in the serum and OVA-specific IgA levels in fecal extracts more prominently than did oral immunization. Cytokine analysis of CD4(+) T cells indicated a predominant induction of Th2-type responses compared to Th1-type responses following rectal immunization compared to oral immunization. These results demonstrate that rectal immunization with microspheres could be an effective new vaccination method. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 21:03:36