Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Rational development of prophylactic HIV vaccines based on structural and regulatory proteins
Autore:
Mooij, P; Heeney, JL;
Indirizzi:
Biomed Primate Res Ctr, Dept Virol, NL-2288 Rijswijk, Netherlands Biomed Primate Res Ctr Rijswijk Netherlands NL-2288 ijswijk, Netherlands
Titolo Testata:
VACCINE
fascicolo: 3-4, volume: 20, anno: 2001,
pagine: 304 - 321
SICI:
0264-410X(20011112)20:3-4<304:RDOPHV>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CYTOTOXIC T-LYMPHOCYTES; TYPE-1 ENVELOPE GLYCOPROTEIN; PROTECTIVE IMMUNE-RESPONSES; ANTIBODY-TITERS CORRELATE; SYNCYTIUM-INDUCING HIV-1; HERPES-SIMPLEX VIRUS; CLASS-I MOLECULES; CTL ESCAPE VIRUS; RHESUS MACAQUES;
Keywords:
HIV; vaccine development; immune correlates; multicomponent;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
217
Recensione:
Indirizzi per estratti:
Indirizzo: Heeney, JL Biomed Primate Res Ctr, Dept Virol, POB 3306, NL-2288 Rijswijk,Netherlands Biomed Primate Res Ctr POB 3306 Rijswijk Netherlands NL-2288 s
Citazione:
P. Mooij e J.L. Heeney, "Rational development of prophylactic HIV vaccines based on structural and regulatory proteins", VACCINE, 20(3-4), 2001, pp. 304-321

Abstract

The severity of the AIDS epidemic clearly emphasises the urgent need to expedite HIV vaccine candidates into clinical trials. Prophylactic HIV vaccine candidates have been evaluated in non-human primates. Based on specific proof of principle studies the first phase III clinical studies have recently begun in humans. However, a truly effective HIV vaccine is not yet at hand and many problems related to specific properties of the virus remain to be overcome. Previously proven empirical approaches have largely failed and now rational thinking based on an understanding of immunity to lentiviral infections is needed. This review addresses the scientific problems and complications facing the development of an HIV vaccine as well as the possible strategies currently available to overcome these problems. Recent attentionhas focussed on identifying the immune correlates and mechanisms of protection from either HIV infection or protection from disease progression. Based on these observations, the logic and rational behind the development of multiple component vaccine strategies are highlighted. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 16:39:58