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Titolo:
Voltammetry of the anticancer drug mitoxantrone and DNA
Autore:
Erdem, A; Ozsoz, M;
Indirizzi:
Ege Univ, Dept Analyt Chem, Fac Pharm, TR-35100 Izmir, Turkey Ege Univ Izmir Turkey TR-35100 t Chem, Fac Pharm, TR-35100 Izmir, Turkey
Titolo Testata:
TURKISH JOURNAL OF CHEMISTRY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 469 - 475
SICI:
1300-0527(2001)25:4<469:VOTADM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUARTZ-CRYSTAL MICROBALANCE; ACID-MODIFIED ELECTRODES; HEPATITIS-B VIRUS; ELECTROCHEMICAL BIOSENSOR; CYCLIC VOLTAMMETRY; NUCLEIC-ACIDS; MITOMYCIN-C; SPECTROSCOPY; DAUNOMYCIN; INDICATOR;
Keywords:
mitoxantrone; biosensors; DNA; voltammetry; intercalation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Ozsoz, M Ege Univ, Dept Analyt Chem, Fac Pharm, TR-35100 Izmir, Turkey EgeUniv Izmir Turkey TR-35100 ac Pharm, TR-35100 Izmir, Turkey
Citazione:
A. Erdem e M. Ozsoz, "Voltammetry of the anticancer drug mitoxantrone and DNA", TURK J CHEM, 25(4), 2001, pp. 469-475

Abstract

The interaction of mitoxantrone (MTX) with calf thymus double-stranded DNA(dsDNA) and calf thymus single-stranded DNA (ssDNA) was studied electrochemically by using differential pulse voltammetry (DPV) and cyclic voltammetry (CV) at a carbon paste electrode (CPE). The changes in the experimental parameters (the concentration of MTX, the concentration of DNA and the accumulation time of MTX) were studied by DPV; in addition, the detection limit and the reproducibility were determined. It was observed for the interaction of MTX with dsDNA and ssDNA that the signal of the bare electrode was higher than the signal of the dsDNA modified CPE. The signals in the cyclic voltammograms were found to be decreasing in the following order: bare CPE, ssDNA modified and dsDNA modified CPE.

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Documento generato il 23/01/21 alle ore 02:52:07