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Titolo:
gamma-secretase: Never more enigmatic
Autore:
Sisodia, SS; Annaert, W; Kim, SH; De Strooper, B;
Indirizzi:
Univ Chicago, Ctr Mol Neurobiol, Dept Neurobiol Pharmacol & Physiol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 rmacol & Physiol, Chicago, IL 60637 USA Catholic Univ Louvain, Ctr Human Genet, Neuronal Cell Biol Lab, B-3000 Louvain, Belgium Catholic Univ Louvain Louvain Belgium B-3000 ab, B-3000 Louvain, Belgium Flanders Interuniv Inst Biotechnol, B-3000 Louvain, Belgium Flanders Interuniv Inst Biotechnol Louvain Belgium B-3000 uvain, Belgium
Titolo Testata:
TRENDS IN NEUROSCIENCES
fascicolo: 11, volume: 24, anno: 2001, supplemento:, S
pagine: S2 - S6
SICI:
0166-2236(200111)24:11<S2:GNME>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; FAMILIAL ALZHEIMERS-DISEASE; INTRACELLULAR DOMAIN; BETA-PROTEIN; PRESENILIN-1; CLEAVAGE; NOTCH; RELEASE; ENDOPROTEOLYSIS; DEFICIENCY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Sisodia, SS Univ Chicago, Ctr Mol Neurobiol, Dept Neurobiol Pharmacol & Physiol, Abbott 501,947 E 58th St, Chicago, IL 60637 USA Univ Chicago Abbott 501,947 E 58th St Chicago IL USA 60637 USA
Citazione:
S.S. Sisodia et al., "gamma-secretase: Never more enigmatic", TRENDS NEUR, 24(11), 2001, pp. S2-S6

Abstract

It is widely believed that the pathogenesis of Alzheimer's disease (AD) isintimately, if not causatively, associated with the deposition of similar to4 kDa beta -amyloid (A beta) peptides in the cerebral cortex and hippocampus of affected individuals. A beta peptides are liberated from transmembrane proteins, termed beta -amyloid precursor proteins (APP), by the concerted action of beta- and gamma -secretase(s). Whereas the identity of beta -secretase is no longer in question, the identity of gamma -secretase, which is responsible for the intramembranous processing of APP, has never been more enigmatic. Considerable evidence has accrued to impugn the presenilins (PS) as the executioners of intramembranous processing of APR Here, we summarize these observations and review recent evidence that argues against the prevailing hypothesis that PS function as gamma -secretases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:32:18