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OPAC HELP

Titolo:
Atopic disorders: a vaccine around the corner?
Autore:
Wohlleben, G; Erb, KJ;
Indirizzi:
Univ Wurzburg, Ctr Infect Dis, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 ct Dis, D-97070 Wurzburg, Germany
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 11, volume: 22, anno: 2001,
pagine: 618 - 626
SICI:
1471-4906(200111)22:11<618:ADAVAT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4(+) T-CELLS; INDUCED AIRWAY HYPERRESPONSIVENESS; INDUCED EOSINOPHIL RECRUITMENT; PRODUCE LATENT TGF-BETA-1; ALLERGEN-SPECIFIC TH1; CPG OLIGODEOXYNUCLEOTIDES; DENDRITIC CELLS; MURINE MODEL; BACTERIAL-DNA; PLASMID DNA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Erb, KJ Univ Wurzburg, Ctr Infect Dis, Rontgenring 11, D-97070 Wurzburg, Germany Univ Wurzburg Rontgenring 11 Wurzburg Germany D-97070 rg, Germany
Citazione:
G. Wohlleben e K.J. Erb, "Atopic disorders: a vaccine around the corner?", TRENDS IMMU, 22(11), 2001, pp. 618-626

Abstract

The incidence and severity of atopic disorders, in particular asthma, is steadily increasing at an alarming rate. Furthermore, no primary prevention measure exists to date. However, recent results obtained from numerous animal studies suggest that primary prevention in humans might be possible in the near future. The most promising approaches include the induction of systemic or local allergen-dependent or -independent T helper 1 (Th1) immune responses, through the use of killed bacteria (or components derived from them), CpG oligodeoxynucleotides or plasmid DNA, and the induction of allergen-specific T-cell tolerance. Here, we review the data showing that animals can be protected from developing allergic Th2 responses by vaccination. Possible future use in humans and potential side-effects of the described vaccination strategies are discussed also.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:19:25